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MiR-219-5p inhibits hepatocellular carcinoma cell proliferation by targeting glypican-3.

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Affiliations

  • 1. Department of Oncology, Nanfang Hospital of Southern Medical University, Guangzhou 510515, Guangdong Province, China.
      Authors
    • Huang N 1
    (1 author)

FEBS Letters, 20 Feb 2012, 586(6):884-891
https://doi.org/10.1016/j.febslet.2012.02.017 PMID: 22449976 

Abstract 

MicroRNAs (miRNAs) have been linked to the molecular pathogenesis of many cancers. In this study, we found that miR-219-5p was significantly downregulated in 83 HCC tissues and three HCC cell lines, compared to their non-tumor counterparts. MiR-219-5p expression correlated with tumor size, histological differentiation, and overall survival time in HCC patients. We also found that miR-219-5p could inhibit cell proliferation in vitro and arrest cell cycle at the G1 to S transition. Further studies identified that miR-219-5p reduced both the mRNA and protein levels of glypican-3 (GPC3). These findings indicate that miR-219-5p exerts tumor-suppressive effects in hepatic carcinogenesis through negative regulation of GPC3 expression.

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Read article at publisher's site: https://doi.org/10.1016/j.febslet.2012.02.017

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