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Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming.

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Affiliations

  • 1. Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan.
      Authors
    • Mitsuishi Y 1
    (1 author)

ORCIDs linked to this article

Cancer Cell, 01 Jul 2012, 22(1):66-79
https://doi.org/10.1016/j.ccr.2012.05.016 PMID: 22789539 

A comment on this article appears in "Nrf2 orchestrates fuel partitioning for cell proliferation." Cell Metab. 2012 Aug 8;16(2):139-41.

Abstract 

Cancer cells consume large quantities of nutrients and maintain high levels of anabolism. Recent studies revealed that various oncogenic pathways are involved in modulation of metabolism. Nrf2, a key regulator for the maintenance of redox homeostasis, has been shown to contribute to malignant phenotypes of cancers including aggressive proliferation. However, the mechanisms with which Nrf2 accelerates proliferation are not fully understood. Here, we show that Nrf2 redirects glucose and glutamine into anabolic pathways, especially under the sustained activation of PI3K-Akt signaling. The active PI3K-Akt pathway augments the nuclear accumulation of Nrf2 and enables Nrf2 to promote metabolic activities that support cell proliferation in addition to enhancing cytoprotection. The functional expansion of Nrf2 reinforces the metabolic reprogramming triggered by proliferative signals.

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Read article at publisher's site: https://doi.org/10.1016/j.ccr.2012.05.016

Read article for free, from open access legal sources, via Unpaywall: http://www.cell.com/article/S1535610812002152/pdfUnpaywall

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