Europe PMC

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Thermally reversible xyloglucan gels as vehicles for nasal drug delivery.

Author information

Affiliations

  • 1. Department of Pharmaceutics and Quality Assurance, R. C. Patel Institute of Pharmaceutical Education and Research, Karvand Naka Shirpur, Dist Dhule, Shirpur, India.
      Authors
    • Mahajan HS 1
    (1 author)

ORCIDs linked to this article

Drug Delivery, 01 Jun 2012, 19(5):270-276
https://doi.org/10.3109/10717544.2012.704095 PMID: 22823894 

Abstract 

The aim of this study was to investigate the potential application of thermosensitive gels formed by a xyloglucan polysaccharide derived from tamarind seed for nasal drug delivery. Xyloglucan that had been partially degraded by β-galactosidase to eliminate 45% of galactose residues formed gels at concentrations of 2.5% w/w at gelation temperatures decreasing over the range 27-28°C. The in vitro release of ondansetron hydrochloride from the enzyme-degraded xyloglucan gels followed higuchi kinetics over a period of 5 h at 34°C by anomalous transport mechanism. The ex vivo permeation of ondansetron hydrochloride from the gels was sustained. Histological examination of nasal mucosa following a single administration of the gels showed no evidence of mucosal damage. Finally, the bioavailability study in rabbits revealed that the absolute bioavailability of ondansetron hydrochloride was significantly increased from 28.64% in the case of the oral drug solution to 52.79% in the case of the nasal in situ gel. The results of this study suggest the potential of the enzyme-degraded xyloglucan gels as vehicles for nasal delivery of drugs.

Full text links 

Read article at publisher's site: https://doi.org/10.3109/10717544.2012.704095

Read article for free, from open access legal sources, via Unpaywall: https://www.tandfonline.com/doi/pdf/10.3109/10717544.2012.704095?needAccess=trueUnpaywall

References 

Articles referenced by this article (25)

Show 10 more references (10 of 25)

Citations & impact 

Impact metrics

16
Citations
Jump to Citations

Citations of article over time

Alternative metrics

Altmetric item for https://www.altmetric.com/details/104942111
Altmetric
Discover the attention surrounding your research
https://www.altmetric.com/details/104942111

Article citations

Go to all (16) article citations

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.