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Introns in UTRs: why we should stop ignoring them.

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Affiliations

  • 1. Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, USA.
      Authors
    • Bicknell AA 1
    (1 author)

ORCIDs linked to this article

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology, 26 Oct 2012, 34(12):1025-1034
https://doi.org/10.1002/bies.201200073 PMID: 23108796 

Abstract 

Although introns in 5'- and 3'-untranslated regions (UTRs) are found in many protein coding genes, rarely are they considered distinctive entities with specific functions. Indeed, mammalian transcripts with 3'-UTR introns are often assumed nonfunctional because they are subject to elimination by nonsense-mediated decay (NMD). Nonetheless, recent findings indicate that 5'- and 3'-UTR intron status is of significant functional consequence for the regulation of mammalian genes. Therefore these features should be ignored no longer.

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Read article at publisher's site: https://doi.org/10.1002/bies.201200073

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Funding 

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Howard Hughes Medical Institute