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The α2δ subunits of voltage-gated calcium channels.

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Affiliations

  • 1. Department of Neuroscience, Physiology and Pharmacology, University College London, UK.
      Authors
    • Dolphin AC 1
    (1 author)

ORCIDs linked to this article

Biochimica et Biophysica Acta, 27 Nov 2012, 1828(7):1541-1549
https://doi.org/10.1016/j.bbamem.2012.11.019 PMID: 23196350 

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Abstract 

Voltage-gated calcium channels consist of the main pore-forming α1 subunit, together, except in the case of the T-type channels, with β and α2δ and sometimes γ subunits, which are collectively termed auxiliary or accessory subunits. This review will concentrate on the properties and role of the α2δ subunits of these channels. These proteins are largely extracellular, membrane-associated proteins which influence the trafficking, localization, and biophysical properties of the channels. This article is part of a Special Issue entitled: Calcium channels.

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Wellcome Trust