Europe PMC

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

In vitro pathogenicity assay for anti-desmoglein autoantibodies in pemphigus.

Author information

Affiliations

  • 1. Department of Dermatology, Toho University, School of Medicine, Tokyo, Japan.
      Authors
    • Ishii K 1
    (1 author)

Methods in Molecular Biology (Clifton, N.J.), 01 Jan 2013, 961:219-225
https://doi.org/10.1007/978-1-62703-227-8_13 PMID: 23325646 

Abstract 

Patients with pemphigus have circulating anti-desmoglein (Dsg) 1 and/or Dsg3 autoantibodies that induce blister formation on the skin and mucous membrane. We describe here two assays that measure the pathogenic strength of autoantibodies in blister formation: an in vitro dissociation assay using primary human epidermal keratinocytes to assess pathogenicity of anti-Dsg3 autoantibodies, and an alternative method whereby anti-Dsg3 and Dsg1 autoantibodies are injected into organ-cultured human skin specimen.

Full text links 

Read article at publisher's site: https://doi.org/10.1007/978-1-62703-227-8_13

Citations & impact 

Impact metrics

7
Citations
Jump to Citations

Citations of article over time

Smart citations by scite.ai
Smart citations by scite.ai include citation statements extracted from the full text of the citing article. The number of the statements may be higher than the number of citations provided by EuropePMC if one paper cites another multiple times or lower if scite has not yet processed some of the citing articles.
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1007/978-1-62703-227-8_13

Supporting
Mentioning
Contrasting
1
12
0

Article citations

Go to all (7) article citations

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.