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Effect of chronic noise exposure on expression of N-methyl-D-aspartic acid receptor 2B and Tau phosphorylation in hippocampus of rats.

Author information

Affiliations

  • 1. Department of Occupational Hygiene, Institute of Health and Environmental Medicine, Academy of Military Medical Sciences, Tianjin 300050, China.
      Authors
    • Cui B 1
    (1 author)

Biomedical and Environmental Sciences : BES, 01 Mar 2013, 26(3):163-168
https://doi.org/10.3967/0895-3988.2013.03.002 PMID: 23425798 

Abstract 

Objective

To study the effect of chronic noise exposure on expression of N-methyl-D-aspartic acid receptor 2B (NR2B) and tau phosphorylation in hippocampus of rats.

Methods

Twenty-four male SD rats were divided in control group and chronic noise exposure group. NR2B expression and tau phosphorylation in hippocampus of rats were detected after chronic noise exposure (100 dB SPL white noise, 4 h/d×30d) and their mechanisms underlying neuronal apoptosis in hippocampus of rats with TUNEL staining.

Results

The NR2B expression decreased significantly after chronic noise exposure which resulted in tau hyperphosphorylation and neural apoptosis in hippocampus of rats. Immunohistochemistry showed that the tau hyperphosphorylation was most prominent in dentate gyrus (DG) and CA1 region of rat hippocampus.

Conclusion

The abnormality of neurotransmitter system, especially Glu and NR2B containing NMDA receptor, and tau hyperphosphorylation in hippocampus of rats, may play a role in chronic noise-induced neural apoptosis and cognition impairment.

Full text links 

Read article at publisher's site: https://doi.org/10.3967/0895-3988.2013.03.002

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