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The kinship of neutrophils and granulocytic myeloid-derived suppressor cells in cancer: cousins, siblings or twins?

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Affiliations

  • 1. Department of Otorhinolaryngology, University Hospital Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, Germany.
      Authors
    • Brandau S 1
    (1 author)

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Seminars in Cancer Biology, 28 Feb 2013, 23(3):171-182
https://doi.org/10.1016/j.semcancer.2013.02.007 PMID: 23459190 

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Abstract 

Neutrophils in the tumor host may promote tumor progression by enhancing angiogenesis, invasion and metastasis. Granulocytic myeloid-derived suppressor cells (MDSC) share many features with neutrophils. Classically, MDSC are viewed as and defined as immunosuppressive cells. In this article we summarize and critically review evidence for a role of MDSC in promoting angiogenesis, invasion and metastasis of solid tumors. We also attempt to provide a critical evaluation of the relationship between neutrophils and G-MDSC in the tumor host with a particular focus on human cancer.

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Read article at publisher's site: https://doi.org/10.1016/j.semcancer.2013.02.007

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