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A clonogenic progenitor with prominent plasmacytoid dendritic cell developmental potential.

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Affiliations

  • 1. Department of Biodefense Research, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
      Authors
    • Onai N 1
    (1 author)

ORCIDs linked to this article

Immunity, 25 Apr 2013, 38(5):943-957
https://doi.org/10.1016/j.immuni.2013.04.006 PMID: 23623382 

A comment on this article appears in "Another heritage for plasmacytoid dendritic cells." Immunity. 2013 May 23;38(5):845-6.

Abstract 

Macrophage and dendritic cell (DC) progenitors (MDPs) and common DC progenitors (CDPs) are bone marrow (BM) progenitors with DC differentiation potential. However, both MDPs and CDPs give rise to large numbers of conventional DCs (cDCs) and few plasmacytoid DCs (pDCs), implying that more dedicated pDC progenitors remain to be identified. Here we have described DC progenitors with a prominent pDC differentiation potential. Although both MDPs and CDPs express the macrophage colony stimulating factor (M-CSF) receptor (M-CSFR), the progenitors were confined to a M-CSFR(-) fraction, identified as Lin(-)c-Kit(int/lo)Flt3(+)M-CSFR(-), and expressed high amounts of E2-2 (also known as Tcf4) an essential transcription factor for pDC development. Importantly, they appeared to be directly derived from either CDPs or lymphoid-primed multipotent progenitors (LMPPs). Collectively, our findings provide insight into DC differentiation pathways and may lead to progenitor-based therapeutic applications for infection and autoimmune disease.

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Read article at publisher's site: https://doi.org/10.1016/j.immuni.2013.04.006

Read article for free, from open access legal sources, via Unpaywall: http://www.cell.com/article/S107476131300160X/pdfUnpaywall

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Funding 

Funders who supported this work.

Core Research for Evolutional Science and Technology

    Japan Science and Technology Agency

      Ministry of Education, Culture, Sports, Science and Technology

        Novartis Foundation

          Sumitomo Foundation

            Takeda Science Foundation

              Uehara Memorial Foundation