Folate: metabolism, genes, polymorphisms and the associated diseases.

Nazki FH; Sameer AS; Ganaie BA

doi:10.1016/j.gene.2013.09.063

Folate: metabolism, genes, polymorphisms and the associated diseases.

Nazki FH ¹,

Sameer AS ,

Ganaie BA

Affiliations

1. Department of Biochemistry, University of Kashmir, Hazratbal, Srinagar, Kashmir 190006, India.
Authors
Nazki FH¹
(1 author)

ORCIDs linked to this article

Gene, 01 Oct 2013, 533(1):11-20
https://doi.org/10.1016/j.gene.2013.09.063 PMID: 24091066

Review

Abstract

Folate being an important vitamin of B Complex group in our diet plays an important role not only in the synthesis of DNA but also in the maintenance of methylation reactions in the cells. Folate metabolism is influenced by several processes especially its dietary intake and the polymorphisms of the associated genes involved. Aberrant folate metabolism, therefore, affects both methylation as well as the DNA synthesis processes, both of which have been implicated in the development of various diseases. This paper reviews the current knowledge of the processes involved in folate metabolism and consequences of deviant folate metabolism, particular emphasis is given to the polymorphic genes which have been implicated in the development of various diseases in humans, like vascular diseases, Down's syndrome, neural tube defects, psychiatric disorders and cancers.

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References

Articles referenced by this article (147)

5,10-methylenetetrahydrofolate reductase (MTHFR) polymorphisms and the risk of acute lymphoblastic leukemia (ALL) in Filipino children.
Alcasabas P, Ravindranath Y, Goyette G, Haller A, Del Rosario L, Lesaca-Medina MY, Darga L, Ostrea EM Jr, Taub JW, Everson RB
Pediatr Blood Cancer, (2):178-182 2008
MED: 18421714
Contribution of the MTHFR gene to the causal pathway for depression, anxiety and cognitive impairment in later life.
Almeida OP, Flicker L, Lautenschlager NT, Leedman P, Vasikaran S, van Bockxmeer FM
Neurobiol Aging, (2):251-257 2005
MED: 15582752
Methylenetetrahydrofolate reductase gene C677T polymorphism, homocysteine, vitamin B12, and DNA damage in coronary artery disease.
Andreassi MG, Botto N, Cocci F, Battaglia D, Antonioli E, Masetti S, Manfredi S, Colombo MG, Biagini A, Clerico A
Hum Genet, (2):171-177 2002
MED: 12522558
Folate receptors
Antony AC
Annu Rev Nutr, 501-521 1996
AGR: IND20541017
Hyperhomocysteinemia is related to residual glomerular filtration and folate, but not to methylenetetrahydrofolate-reductase and methionine synthase polymorphisms, in supplemented end-stage renal disease patients undergoing hemodialysis.
Anwar W, Gueant JL, Abdelmouttaleb I, Adjalla C, Gerard P, Lemoel G, Erraess N, Moutabarrek A, Namour F
Clin Chem Lab Med, (8):747-752 2001
MED: 11592445
Folate metabolism and requirements.
Bailey LB, Gregory JF 3rd
J Nutr, (4):779-782 1999
MED: 10203550
Prevention of neural-tube defects with folic acid in China. China-U.S. Collaborative Project for Neural Tube Defect Prevention.
Berry RJ, Li Z, Erickson JD, Li S, Moore CA, Wang H, Mulinare J, Zhao P, Wong LY, Gindler J, Hong SX, Correa A
N Engl J Med, (20):1485-1490 1999
MED: 10559448
Genetic polymorphisms involved in folate metabolism and elevated plasma concentrations of homocysteine: maternal risk factors for Down syndrome in Brazil.
Biselli JM, Goloni-Bertollo EM, Zampieri BL, Haddad R, Eberlin MN, Pavarino-Bertelli EC
Genet Mol Res, (1):33-42 2008
MED: 18273817
Folate, vitamin B12, homocysteine, and the MTHFR 677C->T polymorphism in anxiety and depression: the Hordaland Homocysteine Study.
Bjelland I, Tell GS, Vollset SE, Refsum H, Ueland PM
Arch Gen Psychiatry, (6):618-626 2003
MED: 12796225
Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects.
Blom HJ, Smulders Y
J Inherit Metab Dis, (1):75-81 2010
MED: 20814827

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Search life-sciences literature (45,104,206 articles, preprints and more)

Folate: metabolism, genes, polymorphisms and the associated diseases.

Affiliations

Authors

ORCIDs linked to this article

Abstract

Full text links

References

5,10-methylenetetrahydrofolate reductase (MTHFR) polymorphisms and the risk of acute lymphoblastic leukemia (ALL) in Filipino children.

Contribution of the MTHFR gene to the causal pathway for depression, anxiety and cognitive impairment in later life.

Methylenetetrahydrofolate reductase gene C677T polymorphism, homocysteine, vitamin B12, and DNA damage in coronary artery disease.

Folate receptors

Hyperhomocysteinemia is related to residual glomerular filtration and folate, but not to methylenetetrahydrofolate-reductase and methionine synthase polymorphisms, in supplemented end-stage renal disease patients undergoing hemodialysis.

Folate metabolism and requirements.

Prevention of neural-tube defects with folic acid in China. China-U.S. Collaborative Project for Neural Tube Defect Prevention.

Genetic polymorphisms involved in folate metabolism and elevated plasma concentrations of homocysteine: maternal risk factors for Down syndrome in Brazil.

Folate, vitamin B12, homocysteine, and the MTHFR 677C->T polymorphism in anxiety and depression: the Hordaland Homocysteine Study.

Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects.

Citations & impact

Impact metrics

Citations of article over time

Alternative metrics

Article citations

Unveiling the Therapeutic Potential of Folate-Dependent One-Carbon Metabolism in Cancer and Neurodegeneration.

Dietary Pattern's Role in Hepatic Epigenetic and Dietary Recommendations for the Prevention of NAFLD.

Polymorphism of Folate Metabolism Genes among Ethnic Kazakh Women with Preeclampsia in Kazakhstan: A Descriptive Study.

Accumulation of 5-methyltetrahydrofolate and other bioactive compounds, in the course of fermentation of green tea (Camellia sinensis) kombucha.

Exploring Gene-Diet Interactions for Mother-Child Health: A Systematic Review of Epidemiological Studies.

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Folate: metabolism, genes, polymorphisms and the associated diseases.

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