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YB-1 protein: functions and regulation.

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Affiliations

  • 1. Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow Region, Russia.
      Authors
    • Lyabin DN 1
    (1 author)

Wiley Interdisciplinary reviews. RNA, 11 Nov 2013, 5(1):95-110
https://doi.org/10.1002/wrna.1200 PMID: 24217978 

Review

Abstract 

The Y-box binding protein 1 (YB-1, YBX1) is a member of the family of DNA- and RNA-binding proteins with an evolutionarily ancient and conserved cold shock domain. It falls into a group of intrinsically disordered proteins that do not follow the classical rule 'one protein-one function' but introduce a novel principle stating that a disordered structure suggests many functions. YB-1 participates in a wide variety of DNA/RNA-dependent events, including DNA reparation, pre-mRNA transcription and splicing, mRNA packaging, and regulation of mRNA stability and translation. At the cell level, the multiple activities of YB-1 are manifested as its involvement in cell proliferation and differentiation, stress response, and malignant cell transformation. WIREs RNA 2014, 5:95-110. doi: 10.1002/wrna.1200 CONFLICT OF INTEREST: The authors have declared no conflicts of interest for this article. For further resources related to this article, please visit the WIREs website.

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Funding 

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Grant of Russian Foundation for Basic Research (1)

Program on �Molecular and Cellular Biology� of the Russian Academy of Sciences

    Program �Basic Sciences to Medicine� of the Russian Academy of Sciences