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A human T cell-specific molecule is a member of a new gene family.

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Affiliations

  • 1. Department of Pediatrics, Stanford University School of Medicine, CA 94305.
      Authors
    • Schall TJ 1
    (1 author)

ORCIDs linked to this article

Journal of Immunology (Baltimore, Md. : 1950), 01 Aug 1988, 141(3):1018-1025
PMID: 2456327 

Abstract 

We have used a cDNA library enriched for T cell-specific sequences to isolate genes expressed by T cells but not by other cell types. We report here one such gene, designated RANTES, which encodes a novel T cell-specific molecule. The RANTES gene product is predicted to be 10 kDa and, after cleavage of the signal peptide, approximately 8 kDa. Of the 68 residues, 4 are cysteines, and there are no sites for N-linked glycosylation. RANTES is expressed by cultured T cell lines that are Ag specific and growth factor dependent. RANTES expression is inducible in PBL by Ag or mitogen. In CTL, expression of RANTES decreases after stimulation with Ag and growth factors. Interestingly, RANTES was not expressed by any T cell tumor line tested. There is significant homology between the RANTES sequence and several other T cell genes, suggesting that they comprise a previously undescribed family of small T cell molecules.

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Free to read at www.jimmunol.org
http://www.jimmunol.org/cgi/content/abstract/141/3/1018

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Funding 

Funders who supported this work.

Intramural NIH HHS (2)

NCI NIH HHS (1)

NIDDK NIH HHS (1)

PHS HHS (1)