Autophagy--a key player in cellular and body metabolism.

Kim KH; Lee MS

doi:10.1038/nrendo.2014.35

Autophagy--a key player in cellular and body metabolism.

Kim KH ¹,

Lee MS ¹

Affiliations

1. Department of Medicine and Samsung Advanced Institute for Health Sciences and Technology, Samsung Medical Centre, Sungkyunkwan University School of Medicine, 81 Irwon-ro Gangnam-gu, Seoul 135-710, Korea.
Authors
Kim KH¹
Lee MS¹
(2 authors)

ORCIDs linked to this article

Kim KH | 0000-0003-2702-9156

Nature reviews. Endocrinology, 25 Mar 2014, 10(6):322-337
https://doi.org/10.1038/nrendo.2014.35 PMID: 24663220

Review

Abstract

Knowledge gained over the past 10 years about the mechanisms that underpin autophagy has provided a universal framework for studies of diverse physiological and pathological processes. Of particular interest is the emerging role of autophagy in the maintenance of energy homeostasis, both at the cellular level and within the organism as a whole. Dysregulation of autophagy might contribute to the development of metabolic disorders, including insulin resistance, diabetes mellitus, obesity, atherosclerosis and osteoporosis. The authors of this Review highlight research findings on the regulation of cellular autophagy by nutrients. They also describe the role of autophagy in various tissues in the regulation of energy metabolism and the development of diseases related to altered metabolism. Finally, the potential of pharmacological modulation of autophagy as a treatment for human metabolic disorders is discussed.

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Read article at publisher's site: https://doi.org/10.1038/nrendo.2014.35

References

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Search life-sciences literature (45,103,589 articles, preprints and more)

Autophagy--a key player in cellular and body metabolism.

Affiliations

Authors

ORCIDs linked to this article

Abstract

Full text links

References

Autophagy plays a protective role in endoplasmic reticulum stress-mediated pancreatic β cell death.

Defective hypothalamic autophagy directs the central pathogenesis of obesity via the IkappaB kinase beta (IKKbeta)/NF-kappaB pathway.

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production.

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes.

Autophagy in Myf5+ progenitors regulates energy and glucose homeostasis through control of brown fat and skeletal muscle development.

A role for NBR1 in autophagosomal degradation of ubiquitinated substrates.

mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6.

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells.

p62 is a key regulator of nutrient sensing in the mTORC1 pathway.

Skeletal muscle is a primary target of SOD1G93A-mediated toxicity.

Citations & impact

Impact metrics

Citations of article over time

Alternative metrics

Article citations

RTA408 alleviates retinal ganglion cells damage in mouse glaucoma by inhibiting excessive autophagy.

NIR-II light based combinatorial management of hypertrophic scar by inducing autophagy in fibroblasts.

The dual role of autophagy in suppressing and promoting hepatocellular carcinoma.

Nanocarrier-Assisted Delivery of Berberine Promotes Diabetic Alveolar Bone Regeneration by Scavenging ROS and Improving Mitochondrial Dysfunction.

Modulation of Autophagy-Lysosome Axis by African Swine Fever Virus and Its Encoded Protein pEP153R.

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Autophagy--a key player in cellular and body metabolism.

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