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The retrovirus HERVH is a long noncoding RNA required for human embryonic stem cell identity.

Author information

Affiliations

  • 1. Gene Regulation Laboratory, Genome Institute of Singapore, Singapore.
      Authors
    • Lu X 1
    • Göke J 1
    (2 authors)
  • 2. 1] Gene Regulation Laboratory, Genome Institute of Singapore, Singapore. [2] Department of Biochemistry, National University of Singapore, Singapore.
      Authors
    • Sachs F 2
    (1 author)
  • 3. Department of Human Genetics, McGill University, Montréal, Québec, Canada.
      Authors
    • Ramsay L 3
    (1 author)
  • 4. 1] Gene Regulation Laboratory, Genome Institute of Singapore, Singapore. [2] Département de Biologie, Université de Sherbrooke, Sherbrooke, Québec, Canada.
      Authors
    • Jacques PÉ 4
    (1 author)
  • 5. 1] Department of Human Genetics, McGill University, Montréal, Québec, Canada. [2] Génome Québec Innovation Center, McGill University, Montréal, Québec, Canada.
      Authors
    • Bourque G 5
    (1 author)
    • Show all (6)

ORCIDs linked to this article

Nature Structural & Molecular Biology, 30 Mar 2014, 21(4):423-425
https://doi.org/10.1038/nsmb.2799 PMID: 24681886 

Abstract 

Human endogenous retrovirus subfamily H (HERVH) is a class of transposable elements expressed preferentially in human embryonic stem cells (hESCs). Here, we report that the long terminal repeats of HERVH function as enhancers and that HERVH is a nuclear long noncoding RNA required to maintain hESC identity. Furthermore, HERVH is associated with OCT4, coactivators and Mediator subunits. Together, these results uncover a new role of species-specific transposable elements in hESCs.

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Funding 

Funders who supported this work.

Canadian Institutes of Health Research (1)