Europe PMC

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Production of monocyte chemotactic and activating factor (MCAF) by human dermal fibroblasts in response to interleukin 1 or tumor necrosis factor.

Author information

Affiliations

  • 1. Division of Cancer Treatment, National Cancer Institute, Frederick, MD 21701.
      Authors
    • Larsen CG 1
    (1 author)

ORCIDs linked to this article

Biochemical and Biophysical Research Communications, 01 May 1989, 160(3):1403-1408
https://doi.org/10.1016/s0006-291x(89)80160-3 PMID: 2471522 

Abstract 

Normal human dermal fibroblasts rapidly expressed (less than 30 min.) considerable mRNA for monocyte chemotactic and activating factor (MCAF) and released high levels of biological activity in response to interleukin 1 (IL 1) or tumor necrosis factor (TNF). In contrast, cultured normal human keratinocytes did not express MCAF mRNA when stimulated with IL 1 or TNF. These results suggest the important role of dermal fibroblasts, the predominant cells in dermal connective tissue, in the recruitment of monocytes during inflammation. This is the first report of the induction of MCAF by IL 1 or TNF in any cell type.

Full text links 

Read article at publisher's site: https://doi.org/10.1016/s0006-291x(89)80160-3

References 

Articles referenced by this article (14)

Show 4 more references (10 of 14)

Citations & impact 

Impact metrics

68
Citations
Jump to Citations

Citations of article over time

Smart citations by scite.ai
Smart citations by scite.ai include citation statements extracted from the full text of the citing article. The number of the statements may be higher than the number of citations provided by EuropePMC if one paper cites another multiple times or lower if scite has not yet processed some of the citing articles.
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1016/s0006-291x(89)80160-3

Supporting
Mentioning
Contrasting
9
167
1

Article citations

Go to all (68) article citations

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.