N-Polybenzylated alicyclic 1,2-diamines: cytotoxicity and G1 phase arrest in cancer cell line.

Caldarelli A; De Biasio V; Giovenzana GB; Mastronardo G; Negri R

doi:10.1007/s11030-014-9519-5

N-Polybenzylated alicyclic 1,2-diamines: cytotoxicity and G1 phase arrest in cancer cell line.

Affiliations

1. Dipartimento di Scienze del Farmaco, Università degli Studi del Piemonte Orientale "A. Avogadro", L.go Donegani 2, I-28100 , Novara NO, Italy.
Authors
Caldarelli A¹
(1 author)

ORCIDs linked to this article

Molecular Diversity, 28 Jun 2014, 18(4):879-886
https://doi.org/10.1007/s11030-014-9519-5 PMID: 24973276

Abstract

Cytotoxicity in the μM range was observed in cancer cell lines treated with N,N,N',N'-tetrabenzyl-4,5-diamino-2-cyclopentenone. Cell cycle analysis on HeLa cells showed a clear G1 phase arrest. A preliminary SAR on structural analogs was performed in order to identify the pharmacophores.

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Read article at publisher's site: https://doi.org/10.1007/s11030-014-9519-5

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N-Polybenzylated alicyclic 1,2-diamines: cytotoxicity and G1 phase arrest in cancer cell line.

Affiliations

Authors

ORCIDs linked to this article

Abstract

Full text links

References

Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008.

Global cancer statistics.

The Chemistry of Vicinal Diamines.

Medicinal agents incorporating the 1,2-diamine functionality.

A new nontricyclic antidepressant agent. Synthesis and activity of N-[trans-2-(dimethylamino)cyclopentyl]-N-(3,4-dichlorophenyl)propanamide and related compounds.

Zubovics Z, Toldy L, Varrò A, Rabloczky G, Kürthy M, Dvortsàk P, Jerkovich G, Tomori E (1986) Synthesis and antiarrhythmic activity of $$N$$ N -arylalkylenediamines. Eur J Med Chem 21:370–378

Synthesis and Antimicrobial Activity of N,N'-Bis(2-hydroxylbenzyl)-1,2-ethanediamine Derivatives.

In vitro antileishmanial, trypanocidal, and Mammalian cell activities of diverse n,n' -dihetaryl substituted diamines and related compounds.

Leishmanicidal and trypanocidal activities of 2-aminocyclohexanol and 1,2-cyclohexanediamine derivatives.

Platinum compounds: a new class of potent antitumour agents.

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Search life-sciences literature (45,104,206 articles, preprints and more)

N-Polybenzylated alicyclic 1,2-diamines: cytotoxicity and G1 phase arrest in cancer cell line.

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Affiliations

Authors

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Abstract

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References

Zubovics Z, Toldy L, Varrò A, Rabloczky G, Kürthy M, Dvortsàk P, Jerkovich G, Tomori E (1986) Synthesis and antiarrhythmic activity of $$N$$ N -arylalkylenediamines. Eur J Med Chem 21:370–378

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