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The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase.

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Affiliations

  • 1. Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322.
      Authors
    • Wilkinson KD 1
    (1 author)

ORCIDs linked to this article

Science, 01 Nov 1989, 246(4930):670-673
https://doi.org/10.1126/science.2530630 PMID: 2530630 

Abstract 

A complementary DNA (cDNA) for ubiquitin carboxyl-terminal hydrolase isozyme L3 was cloned from human B cells. The cDNA encodes a protein of 230 amino acids with a molecular mass of 26.182 daltons. The human protein is very similar to the bovine homolog, with only three amino acids differing in over 100 residues compared. The amino acid sequence deduced from the cDNA was 54% identical to that of the neuron-specific protein PGP 9.5. Purification of bovine PGP 9.5 confirmed that it is also a ubiquitin carboxyl-terminal hydrolase. These results suggest that a family of such related proteins exists and that their expression is tissue-specific.

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Read article at publisher's site: https://doi.org/10.1126/science.2530630

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