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Molecular pathogenesis of Klebsiella pneumoniae.

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Affiliations

  • 1. Department of Dermatology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China.
      Authors
    • Li B 1
    (1 author)

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Future Microbiology, 01 Jan 2014, 9(9):1071-1081
https://doi.org/10.2217/fmb.14.48 PMID: 25340836 

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Abstract 

Typical Klebsiella pneumoniae is an opportunistic pathogen, which mostly affects those with weakened immune systems and tends to cause nosocomial infections. A subset of hypervirulent K. pneumoniae serotypes with elevated production of capsule polysaccharide can affect previously healthy persons and cause life-threatening community-acquired infections, such as pyogenic liver abscess, meningitis, necrotizing fasciitis, endophthalmitis and severe pneumonia. K. pneumoniae utilizes a variety of virulence factors, especially capsule polysaccharide, lipopolysaccharide, fimbriae, outer membrane proteins and determinants for iron acquisition and nitrogen source utilization, for survival and immune evasion during infection. This article aims to present the state-of-the-art understanding of the molecular pathogenesis of K. pneumoniae.

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Read article at publisher's site: https://doi.org/10.2217/fmb.14.48

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Funding 

Funders who supported this work.

Hubei University of Medicine (1)

National Natural Science Foundation of Hubei University of Medicine (1)

the National Basic Research Program of China (1)

the National Key Program for Infectious Disease of China (1)