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Epidermal growth factor receptor-targeted lipid nanoparticles retain self-assembled nanostructures and provide high specificity.

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  • 1. CSIRO Manufacturing Flagship, Private Bag 10, Clayton, VIC 3169, Australia.
      Authors
    • Zhai J 1
    (1 author)

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Nanoscale, 01 Feb 2015, 7(7):2905-2913
https://doi.org/10.1039/c4nr05200e PMID: 25516406 

Abstract 

Next generation drug delivery utilising nanoparticles incorporates active targeting to specific sites. In this work, we combined targeting with the inherent advantages of self-assembled lipid nanoparticles containing internal nano-structures. Epidermal growth factor receptor (EGFR)-targeting, PEGylated lipid nanoparticles using phytantriol and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-PEG-maleimide amphiphiles were created. The self-assembled lipid nanoparticles presented here have internal lyotropic liquid crystalline nano-structures, verified by synchrotron small angle X-ray scattering and cryo-transmission electron microscopy, that offer the potential of high drug loading and enhanced cell penetration. Anti-EGFR Fab' fragments were conjugated to the surface of nanoparticles via a maleimide-thiol reaction at a high conjugation efficiency and retained specificity following conjugation to the nanoparticles. The conjugated nanoparticles were demonstrated to have high affinity for an EGFR target in a ligand binding assay.

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Read article at publisher's site: https://doi.org/10.1039/c4nr05200e

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Commonwealth Scientific and Industrial Research Organisation