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Multiple system atrophy with neuronal intranuclear hyaline inclusions. Report of a case and review of the literature.

Journal of the Neurological Sciences, 01 Jan 1985, 67(1):57-65
https://doi.org/10.1016/0022-510x(85)90022-x PMID: 2580060 

Abstract 

A 31/2-year-old girl presented with frequent falls. She had an unsteady gait, delayed behavioural development absent tendon reflexes and in the legs decreased strength tone and equivocal plantar responses. She then developed ataxia, nystagmus, choreoathetosis, cranial nerve palsies, diminished strength and tone in the arms, sensory deficit in the limbs and autonomic nervous system dysfunction. She became progressively less responsive and succumbed at the age of 63/4 years. Examination of the central, peripheral and autonomic nervous system showed ubiquitous neuronal intranuclear hyaline inclusions and neuronal loss in several sites.

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