Some endocrinological events associated with early pregnancy failure.

Whittaker PG; Stewart MO; Taylor A; Lind T

doi:10.1111/j.1471-0528.1989.tb03198.x

Some endocrinological events associated with early pregnancy failure.

Affiliations

1. MRC Human Reproduction Group, Princess Mary Maternity Hospital, Newcastle Upon Tyne.
Authors
Whittaker PG¹
(1 author)

British Journal of Obstetrics and Gynaecology, 01 Oct 1989, 96(10):1207-1214
https://doi.org/10.1111/j.1471-0528.1989.tb03198.x PMID: 2590657

Abstract

Serial measurements of serum progesterone, oestradiol, human chorionic gonadotrophin (hCG) and human placental lactogen (hPL) have been determined in 33 women experiencing early pregnancy failure and compared with the values of the same hormones in 72 healthy women having uncomplicated pregnancies. Steroid production by the corpus luteum seemed similar in both groups up to 6 weeks gestation but thereafter placental steroidogenesis was not evident in those women in whom spontaneous pregnancy losses occurred. Placental production of the two protein hormones, hCG and hPL, did take place, and whereas the circulating levels were not as high as in normal pregnancies, levels did usually increase before clinical evidence of miscarriage occurred. hCG was not a sensitive discriminator of subsequent failure. In these women there were no significant hormone differences between those with evidence of a fetus and those without.

Full text links

Read article at publisher's site: https://doi.org/10.1111/j.1471-0528.1989.tb03198.x

References

Articles referenced by this article (27)

Some new aspects of the endocrinological response to pregnancy.
Aspillaga MO, Whittaker PG, Taylor A, Lind T
Br J Obstet Gynaecol, (7):596-603 1983
MED: 6871128
Endocrinologic events in early pregnancy failure.
Aspillaga MO, Whittaker PG, Grey CE, Lind T
Am J Obstet Gynecol, (8):903-908 1983
MED: 6650626
Serial beta-subunit human chorionic gonadotropin doubling time as a prognosticator of pregnancy outcome in an infertile population.
Batzer FR, Schlaff S, Goldfarb AF, Corson SL
Fertil Steril, (3):307-312 1981
MED: 7202754
Landmarks during the first forty-two days of gestation demonstrated by the beta-subunit of human chorionic gonadotropin and ultrasound.
Batzer FR, Weiner S, Corson SL, Schlaff S, Otis C
Am J Obstet Gynecol, (8):973-979 1983
MED: 6192720
Title not supplied
Biswas
J Obstet Gynaecol 1980
First-trimester chorionic gonadotropin measurements as an aid in the diagnosis of early pregnancy disorders.
Braunstein GD, Karow WG, Gentry WC, Rasor J, Wade ME
Am J Obstet Gynecol, (1):25-32 1978
MED: 645779
hCG free beta-subunit an early marker of outcome of in vitro fertilization clinical pregnancies.
Cole LA, Restrepo-Candelo H, Lavy G, Decherney A
J Clin Endocrinol Metab, (6):1328-1330 1987
MED: 2437141
The predictive value of hCG beta subunit levels in pregnancies achieved by in vitro fertilization and embryo transfer: an international collaborative study.
Confino E, Demir RH, Friberg J, Gleicher N
Fertil Steril, (4):526-531 1986
MED: 2420652
Indispensability of the human corpus luteum in the maintenance of early pregnancy. Luteectomy evidence.
Csapo AI, Pulkkinen M
Obstet Gynecol Surv, (2):69-81 1978
MED: 341008
Pregnancy-specific parameters in early pregnancies after in vitro fertilization: prediction of the course of pregnancy.
Deutinger J, Neumark J, Reinthaller A, Riss P, Muller-Tyl E, Fischl F, Bieglmayer C, Janisch H
Fertil Steril, (1):77-80 1986
MED: 2424793

Show 10 more references (10 of 27)

Citations & impact

Impact metrics

Citations

Jump to Citations

Citations of article over time

Smart citations by scite.ai
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1111/j.1471-0528.1989.tb03198.x

Supporting

Mentioning

Contrasting

Article citations

Gestational hormone trajectories and early pregnancy failure: a reassessment.
Whittaker PG, Schreiber CA, Sammel MD
Reprod Biol Endocrinol, 16(1):95, 11 Oct 2018
Cited by: 10 articles | PMID: 30309358 | PMCID: PMC6182860
This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
Free full text in Europe PMC
Inhibin A and activin A may be used to predict pregnancy outcome in women with recurrent miscarriage.
Prakash A, Laird S, Tuckerman E, Li TC, Ledger WL
Fertil Steril, 83(6):1758-1763, 01 Jun 2005
Cited by: 23 articles | PMID: 15950648
Transcription of cholesterol side-chain cleavage cytochrome P450 in the placenta: activating protein-2 assumes the role of steroidogenic factor-1 by binding to an overlapping promoter element.
Ben-Zimra M, Koler M, Orly J
Mol Endocrinol, 16(8):1864-1880, 01 Aug 2002
Cited by: 32 articles | PMID: 12145340
The role of a single progesterone measurement in the diagnosis of early pregnancy failure and the prognosis of fetal viability.
al-Sebai MA, Kingsland CR, Diver M, Hipkin L, McFadyen IR
Br J Obstet Gynaecol, 102(5):364-369, 01 May 1995
Cited by: 27 articles | PMID: 7612529
Serum concentrations of human chorionic gonadotrophin and immunoreactive inhibin in early pregnancy and recurrent miscarriage: a longitudinal study.
France JT, Keelan J, Song L, Liddell H, Zanderigo A, Knox B
Aust N Z J Obstet Gynaecol, 36(3):325-330, 01 Aug 1996
Cited by: 9 articles | PMID: 8883762

Go to all (13) article citations

Search life-sciences literature (45,103,589 articles, preprints and more)

Some endocrinological events associated with early pregnancy failure.

Affiliations

Authors

Abstract

Full text links

References

Some new aspects of the endocrinological response to pregnancy.

Endocrinologic events in early pregnancy failure.

Serial beta-subunit human chorionic gonadotropin doubling time as a prognosticator of pregnancy outcome in an infertile population.

Landmarks during the first forty-two days of gestation demonstrated by the beta-subunit of human chorionic gonadotropin and ultrasound.

Title not supplied

First-trimester chorionic gonadotropin measurements as an aid in the diagnosis of early pregnancy disorders.

hCG free beta-subunit an early marker of outcome of in vitro fertilization clinical pregnancies.

The predictive value of hCG beta subunit levels in pregnancies achieved by in vitro fertilization and embryo transfer: an international collaborative study.

Indispensability of the human corpus luteum in the maintenance of early pregnancy. Luteectomy evidence.

Pregnancy-specific parameters in early pregnancies after in vitro fertilization: prediction of the course of pregnancy.

Citations & impact

Impact metrics

Citations of article over time

Smart citations by scite.ai
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1111/j.1471-0528.1989.tb03198.x

Article citations

Gestational hormone trajectories and early pregnancy failure: a reassessment.

Inhibin A and activin A may be used to predict pregnancy outcome in women with recurrent miscarriage.

Transcription of cholesterol side-chain cleavage cytochrome P450 in the placenta: activating protein-2 assumes the role of steroidogenic factor-1 by binding to an overlapping promoter element.

The role of a single progesterone measurement in the diagnosis of early pregnancy failure and the prognosis of fetal viability.

Serum concentrations of human chorionic gonadotrophin and immunoreactive inhibin in early pregnancy and recurrent miscarriage: a longitudinal study.

Similar Articles

Gestational hormone trajectories and early pregnancy failure: a reassessment.

Endocrinologic events in early pregnancy failure.

Predictive value of hormone determinations in the first half of pregnancy.

Protein and steroid hormones in pregnancy.

Partnerships & funding

Similar Articles

Gestational hormone trajectories and early pregnancy failure: a reassessment.

Endocrinologic events in early pregnancy failure.
Am J Obstet Gynecol, 147(8):903-908, 01 Dec 1983

Predictive value of hormone determinations in the first half of pregnancy.
Eur J Obstet Gynecol Reprod Biol, 17(1):1-17, 01 Apr 1984

Protein and steroid hormones in pregnancy.
J Reprod Med, 23(4):166-177, 01 Oct 1979

Search life-sciences literature (45,103,589 articles, preprints and more)

Some endocrinological events associated with early pregnancy failure.

Author information

Affiliations

Authors

Abstract

Full text links

References

Title not supplied

Citations & impact

Impact metrics

Citations of article over time

Article citations

Similar Articles

Partnerships & funding