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Enhancing the Quality of Antibodies to HIV-1 Envelope by GagPol-Specific Th Cells.

Author information

Affiliations

  • 1. Department of Molecular and Medical Virology, Ruhr-University Bochum, Bochum 44801, Germany;
      Authors
    • Storcksdieck genannt Bonsmann M 1
    • Niezold T 1
    • Nabi G 1
    • Tenbusch M 1
    (4 authors)
  • 2. Department of Molecular and Medical Virology, Ruhr-University Bochum, Bochum 44801, Germany; Universitätsklinikum Erlangen, Institut für Klinische und Molekulare Virologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen 91054, Germany;
      Authors
    • Temchura V 2
    • Überla K 2
    (2 authors)
  • 3. U.S. Military HIV Research Program, Silver Spring, MD 20910;
      Authors
    • Pissani F 3
    • Streeck H 3
    (2 authors)
  • 4. Department of Medical Microbiology and Hygiene, Institute of Virology, University Medical Center Freiburg, Freiburg 79106, Germany;
      Authors
    • Ehrhardt K 4
    • Hengel H 4
    (2 authors)
  • 5. Thayer School of Engineering, Dartmouth College, Hanover, NH 03755; and.
      Authors
    • Brown EP 5
    • Osei-Owusu NY 5
    • Ackerman ME 5
    (3 authors)
    • Show all (6)

ORCIDs linked to this article

Journal of Immunology (Baltimore, Md. : 1950), 14 Oct 2015, 195(10):4861-4872
https://doi.org/10.4049/jimmunol.1501377 PMID: 26466954 

Abstract 

The importance of Fc-dependent effector functions of Abs induced by vaccination is increasingly recognized. However, vaccination of mice against HIV envelope (Env) induced a skewed Th cell response leading to Env-specific Abs with reduced effector function. To overcome this bias, GagPol-specific Th cells were harnessed to provide intrastructural help for Env-specific B cells after immunization with virus-like particles containing GagPol and Env. This led to a balanced Env-specific humoral immune response with a more inflammatory Fc glycan profile. The increased quality in the Ab response against Env was confirmed by FcγR activation assays. Because the Env-specific Th cell response was also biased in human vaccinees, intrastructural help is an attractive novel approach to increase the efficacy of prophylactic HIV Env-based vaccines and may also be applicable to other particulate vaccines.

Full text links 

Read article at publisher's site: https://doi.org/10.4049/jimmunol.1501377

Read article for free, from open access legal sources, via Unpaywall: https://www.jimmunol.org/content/jimmunol/195/10/4861.full.pdfUnpaywall

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