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RhoA is associated with invasion and poor prognosis in colorectal cancer.

Author information

Affiliations

  • 1. Soonchunhyang Medical Science Research Institute, College of Medicine, Soonchunhyang University, Cheonan, Chungcheongnam-do, Republic of Korea.
      Authors
    • Jeong D 1
    • Park S 1
    • Kim H 1
    (3 authors)
  • 2. Department of Pathology, College of Medicine, Soonchunhyang University, Cheonan, Chungcheongnam-do, Republic of Korea.
      Authors
    • Kim CJ 2
    (1 author)
  • 3. Department of Surgery, College of Medicine, Soonchunhyang University, Cheonan, Chungcheongnam-do, Republic of Korea.
      Authors
    • Ahn TS 3
    • Lee MS 3
    • Baek MJ 3
    (3 authors)
  • 4. Department of Oncology, College of Medicine, Soonchunhyang University, Cheonan, Chungcheongnam-do, Republic of Korea.
      Authors
    • Bae SB 4
    • Kim HJ 4
    (2 authors)
  • 5. Department of Chemistry, Soonchunhyang University, Cheonan, Chungcheongnam-do, Republic of Korea.
      Authors
    • Kim TH 5
    (1 author)
    • Show all (7)

ORCIDs linked to this article

International Journal of Oncology, 08 Dec 2015, 48(2):714-722
https://doi.org/10.3892/ijo.2015.3281 PMID: 26648547 

Abstract 

Colorectal cancer is one of the most common cancers and is the fourth leading cause of cancer death in Korea. Mortality of colorectal cancer is strongly associated with the metastatic spread of the disease. As such, it is important to find and characterize signaling pathways involved in colon cancer metastasis. We investigated the functional importance of RhoA using human cell lines as well as 150 colorectal cancer patient-derived samples as it remains unclear whether RhoA functions as either an oncogene or a tumor suppressor in colon cancer. RhoA was highly expressed in metastatic cancer cell lines. Although cancer cell proliferation was only moderately impaired after depletion of RhoA, RhoA-depleted cancer cells exhibited markedly reduced migration and invasion ability in vitro. Furthermore, we found that RhoA is associated with the invasion of lymph nodes and blood vessels in the patient colorectal cancer samples. Most notably, patients with higher RhoA expression had a significantly poorer 5-year survival rate after surgery. These results suggest that RhoA is a marker of poor prognosis in colorectal cancer and may be a promising target for cancer treatment.

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Read article at publisher's site: https://doi.org/10.3892/ijo.2015.3281

Read article for free, from open access legal sources, via Unpaywall: https://www.spandidos-publications.com/10.3892/ijo.2015.3281/downloadUnpaywall

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