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Recent advances in liposome surface modification for oral drug delivery.

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Affiliations

  • 1. Department of Biomedical Engineering, College of Life Science & Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
      Authors
    • Nguyen TX 1
    • Huang L 1
    • Yang G 1
    (3 authors)
  • 2. Department of Chemistry, University of Waterloo, 200 University Ave West, Waterloo, N2L 3G1, Canada.
      Authors
    • Gauthier M 2
    (1 author)
  • 3. Department of Chemical & Biological Engineering, Iowa State University, Ames, IA 50011, USA.
      Authors
    • Wang Q 3
    (1 author)

ORCIDs linked to this article

Nanomedicine (London, England), 13 Apr 2016, 11(9):1169-1185
https://doi.org/10.2217/nnm.16.9 PMID: 27074098 

Review

Abstract 

Oral delivery via the gastrointestinal (GI) tract is the dominant route for drug administration. Orally delivered liposomal carriers can enhance drug solubility and protect the encapsulated theraputic agents from the extreme conditions found in the GI tract. Liposomes, with their fluid lipid bilayer membrane and their nanoscale size, can significantly improve oral absorption. Unfortunately, the clinical applications of conventional liposomes have been hindered due to their poor stability and availability under the harsh conditions typically presented in the GI tract. To overcome this problem, the surface modification of liposomes has been investigated. Although liposome surface modification has been extensively studied for oral drug delivery, no review exists so far that adequately covers this topic. The purpose of this paper is to summarize and critically analyze emerging trends in liposome surface modification for oral drug delivery.

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Read article at publisher's site: https://doi.org/10.2217/nnm.16.9

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Funding 

Funders who supported this work.

Crohn's & Colitis Foundation (1)