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Intratracheal therapy with autologous bone marrow-derived mononuclear cells reduces airway inflammation in horses with recurrent airway obstruction.

Author information

Affiliations

  • 1. Department of Animal Science, Pontifícia Universidade Católica do Paraná, Rua Imaculada Conceição, 1155, Prado Velho, Curitiba, Paraná 80215-901, Brazil.
      Authors
    • Barussi FC 1
    • Bastos FZ 1
    • Pimpão CT 1
    • Michelotto PV Jr 1
    (4 authors)
  • 2. School of Medicine, Experimental Laboratory for Cell Culture, Pontifícia Universidade Católica do Paraná, Rua Imaculada Conceição, 1155, Prado Velho, Curitiba, Paraná 80215-901, Brazil.
      Authors
    • Leite LM 2
    • Fragoso FY 2
    • Senegaglia AC 2
    • Brofman PR 2
    (4 authors)
  • 3. Department of Physiology, Universidade Federal do Paraná, Av. Coronel Francisco Heráclito dos Santos, 210, Jardim das Americas, Curitiba, Paraná 81531-970, Brazil.
      Authors
    • Nishiyama A 3
    (1 author)

ORCIDs linked to this article

Respiratory Physiology & Neurobiology, 07 Jul 2016, 232:35-42
https://doi.org/10.1016/j.resp.2016.07.002 PMID: 27396936 

Abstract 

This research evaluated the effects of bone marrow-derived mononuclear cells (BMMCs) on the inflammatory process in the equine recurrent airway obstruction (RAO). Eight horses in RAO clinical score were divided into cell therapy group (Gcel) treated with a single intratracheal dose of BMMCs, and dexamethasone group (Gdex) treated with 21days of oral dexamethasone. The horses were clinically revaluated on days 7 and 21, together with cytological evaluation of the BALF, and detection of inflammatory markers (interleukins [IL]-10, -4, and -17, and interferon γ and α). There were decreases in respiratory effort and clinical score on days 7 and 21(p<0.05) for both groups. The percentage of neutrophils decreased and macrophages increased on days 7 and 21 (p<0.005) in both groups. IL-10 levels increased in the Gcel group on day 21 compared to days 0 and 7 (p<0.05), but this was not observed in the Gdex group. The quantification of IL-4, IL-17, IFN-γ, and IFN-α did not change between evaluations in both groups. These preliminary results suggest that BMMCs may ameliorate the inflammatory response of RAO.

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Read article at publisher's site: https://doi.org/10.1016/j.resp.2016.07.002

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