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Functional Antibodies and Protection against Blood-stage Malaria.

Author information

Affiliations

  • 1. Department of Medicine, University of Melbourne (Royal Melbourne Hospital), Parkville, Australia; Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia.
      Authors
    • Teo A 1
    (1 author)
  • 2. Burnet Institute for Medical Research and Public Health, 85 Commercial Road, Australia.
      Authors
    • Feng G 2
    (1 author)
  • 3. Department of Medicine, University of Melbourne (Royal Melbourne Hospital), Parkville, Australia; Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia; Victorian Infectious Diseases Service, Doherty Institute for Infection and Immunity, Melbourne, Australia.
      Authors
    • Brown GV 3
    • Rogerson SJ 3
    (2 authors)
  • 4. Department of Medicine, University of Melbourne (Royal Melbourne Hospital), Parkville, Australia; Burnet Institute for Medical Research and Public Health, 85 Commercial Road, Australia; Department of Microbiology, Monash University, Melbourne, Victoria, Australia.
      Authors
    • Beeson JG 4
    (1 author)

ORCIDs linked to this article

Trends in Parasitology, 18 Aug 2016, 32(11):887-898
https://doi.org/10.1016/j.pt.2016.07.003 PMID: 27546781 

Review

Abstract 

Numerous efforts to understand the functional roles of antibodies demonstrated that they can protect against malaria. However, it is unclear which antibody responses are the best correlates of immunity, and which antibody functions are most important in protection from disease. Understanding the role of antibodies in protection against malaria is crucial for antimalarial vaccine design. In this review, the specific functional properties of naturally acquired and vaccine-induced antibodies that correlate to protection from the blood stages of Plasmodium falciparum malaria are re-examined and the gaps in knowledge related to antibody function in malarial immunity are highlighted.

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Read article at publisher's site: https://doi.org/10.1016/j.pt.2016.07.003

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