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Familial longevity study reveals a significant association of mitochondrial DNA copy number between centenarians and their offspring.

Author information

Affiliations

  • 1. State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming, China.
      Authors
    • He YH 1
    • Chen XQ 1
    • Pu SY 1
    • Kong QP 1
    (4 authors)
  • 2. Department of Biochemistry and Molecular Biology, Hainan Medical College, Haikou, China.
      Authors
    • Yan DJ 2
    • Cai WW 2
    (2 authors)
  • 3. State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming, China; Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing, China.
      Authors
    • Xiao FH 3
    • Liu YW 3
    • Yu Q 3
    • Jiang JJ 3
    (4 authors)
  • 4. Department of Biology, Hainan Medical College, Haikou, China.
      Authors
    • Lin R 4
    (1 author)
  • 5. Department of Neurology, The Affiliated Hospital of Hainan Medical College, Haikou, China.
      Authors
    • Liao XP 5
    (1 author)
    • Show all (6)

ORCIDs linked to this article

Neurobiology of Aging, 06 Aug 2016, 47:218.e11-218.e18
https://doi.org/10.1016/j.neurobiolaging.2016.07.026 PMID: 27600867 

Abstract 

Reduced mitochondrial function is an important cause of aging and age-related diseases. We previously revealed a relatively higher level of mitochondrial DNA (mtDNA) content in centenarians. However, it is still unknown whether such an mtDNA content pattern of centenarians could be passed on to their offspring and how it was regulated. To address these issues, we recruited 60 longevity families consisting of 206 family members (cohort 1) and explored their mtDNA copy number. The results showed that the first generation of the offspring (F1 offspring) had a higher level of mtDNA copy number than their spouses (p < 0.05) independent of a gender effect. In addition, we found a positive association of mtDNA copy number in centenarians with that in F1 offspring (r = 0.54, p = 0.0008) but not with that in F1 spouses. These results were replicated in another independent cohort consisting of 153 subjects (cohort 2). RNA sequencing analysis suggests that the single-stranded DNA-binding protein 4 was significantly associated with mtDNA copy number and was highly expressed in centenarians as well as F1 offspring versus the F1 spouses, thus likely regulates the mtDNA copy number in the long-lived family members. In conclusion, our results suggest that the pattern of high mtDNA copy number is likely inheritable, which may act as a favorable factor to familial longevity through assuring adequate energy supply.

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Read article at publisher's site: https://doi.org/10.1016/j.neurobiolaging.2016.07.026

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Funding 

Funders who supported this work.

National Basic Research Program of China (1)

National Natural Science Foundation of China (2)

Youth Innovation Promotion Association of Chinese Academy of Sciences