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A role for a 70-kilodalton heat shock protein in lysosomal degradation of intracellular proteins.

Author information

Affiliations

  • 1. Department of Physiology, Tufts University School of Medicine, Boston, MA 02111.
      Authors
    • Chiang HL 1
    (1 author)

Science, 01 Oct 1989, 246(4928):382-385
https://doi.org/10.1126/science.2799391 PMID: 2799391 

Abstract 

A 73-kilodalton (kD) intracellular protein was found to bind to peptide regions that target intracellular proteins for lysosomal degradation in response to serum withdrawal. This protein cross-reacted with a monoclonal antibody raised to a member of the 70-kD heat shock protein (hsp70) family, and sequences of two internal peptides of the 73-kD protein confirm that it is a member of this family. In response to serum withdrawal, the intracellular concentration of the 73-kD protein increased severalfold. In the presence of adenosine 5'-triphosphate (ATP) and MgCl2, the 73-kD protein enhanced protein degradation in two different cell-free assays for lysosomal proteolysis.

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Read article at publisher's site: https://doi.org/10.1126/science.2799391

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Funding 

Funders who supported this work.

NIA NIH HHS (1)

NIDDK NIH HHS (1)