Europe PMC

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

ACG, the initiator codon for a Sendai virus protein.

Author information

Affiliations

  • 1. Department of Immunology/Microbiology, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612.
      Authors
    • Gupta KC 1
    (1 author)

The Journal of Biological Chemistry, 01 Jun 1988, 263(18):8553-8556
https://doi.org/10.1016/s0021-9258(18)68338-3 PMID: 2837456 

Abstract 

Deletion and site-directed point mutants of the polycistronic P/C mRNA of Sendai virus revealed that one of the nonstructural proteins of this virus, the C' protein, initiates from an ACG codon. This ACG codon occurs in an optimum sequence context and precedes the first AUG of the P/C mRNA. The results presented in this communication are consistent with the concept that the ribosomes scan the P/C mRNA to initiate several proteins from its different initiator codons. The arrangement of several weak initiator codons in tandem in an mRNA, i.e. non-AUG in optimum sequence context and AUG in suboptimum sequence context, may represent an alternate means to regulate gene expression in eukaryotes and their viruses.

Full text links 

Read article at publisher's site: https://doi.org/10.1016/s0021-9258(18)68338-3

Free to read at intl.jbc.org
http://intl.jbc.org/cgi/content/abstract/263/18/8553

Citations & impact 

Impact metrics

58
Citations
Jump to Citations

Citations of article over time

Alternative metrics

Altmetric item for https://www.altmetric.com/details/105385185
Altmetric
Discover the attention surrounding your research
https://www.altmetric.com/details/105385185

Article citations

Go to all (58) article citations

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.