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Metabolic reprograming of anti-tumor immunity.

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Affiliations

  • 1. Center for Cell-Based Therapy, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA; Surgery Branch, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
      Authors
    • Sukumar M 1
    • Kishton RJ 1
    • Restifo NP 1
    (3 authors)

ORCIDs linked to this article

Current Opinion in Immunology, 13 Apr 2017, 46:14-22
https://doi.org/10.1016/j.coi.2017.03.011 PMID: 28412583 PMCID: PMC6327315

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Abstract 

Immunotherapies designed to trigger T cell destruction of tumor cells can result in sustained and complete responses in patients whose cancers were resistant to available treatment options. Evidence suggests that powering the T cell response - how T cells generate energy - plays an important role in their effectiveness. Furthermore the metabolism of T cells can be modulated to improve their anti-cancer activities. In this review, we will discuss the key metabolic properties of anti-cancer T cells, along with potential strategies to enhance immunotherapy through the modulation of T cell metabolism.

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Funding 

Funders who supported this work.

Intramural NIH HHS (2)