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The role of lactic acid production by probiotic Lactobacillus species in vaginal health.

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Affiliations

  • 1. Centre for Biomedical Research, Burnet Institute, 85 Commercial Rd, Melbourne, Victoria 3004, Australia; Department of Microbiology, Monash University, 19 Innovation Walk, Clayton, Victoria 3168, Australia; Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, University of Melbourne, 792 Elizabeth Street, Melbourne, Victoria 3000, Australia; School of Science, College of Science, Engineering and Health, RMIT University, Melbourne, Victoria 3000, Australia.
      Authors
    • Tachedjian G 1
    (1 author)
  • 2. Centre for Biomedical Research, Burnet Institute, 85 Commercial Rd, Melbourne, Victoria 3004, Australia; Department of Microbiology, Monash University, 19 Innovation Walk, Clayton, Victoria 3168, Australia.
      Authors
    • Aldunate M 2
    (1 author)
  • 3. Melbourne Sexual Health Centre, 580 Swanston St, Carlton, Victoria 3053, Australia; Central Clinical School, Monash University, Melbourne, Victoria 3004, Australia.
      Authors
    • Bradshaw CS 3
    (1 author)
  • 4. Department of Biophysics, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD, USA.
      Authors
    • Cone RA 4
    (1 author)

ORCIDs linked to this article

Research in Microbiology, 20 Apr 2017, 168(9-10):782-792
https://doi.org/10.1016/j.resmic.2017.04.001 PMID: 28435139 

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Abstract 

Vaginal eubiosis is characterised by beneficial lactobacillus-dominated microbiota. In contrast, vaginal dysbiosis (e.g. bacterial vaginosis, BV), characterised by an overgrowth of multiple anaerobes, is associated with an increased risk of adverse urogenital and reproductive health outcomes. A major distinguishing feature between the vaginal environment in states of eubiosis and dysbiosis is a high concentration of lactic acid, produced by lactobacilli, that acidifies the vagina in eubiosis versus a sharp drop in lactic acid and an increase in pH in dysbiosis. Here we review the antimicrobial, antiviral and immunomodulatory properties of lactic acid and the use of lactic acid and lactobacilli probiotics in preventing or treating BV.

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Read article at publisher's site: https://doi.org/10.1016/j.resmic.2017.04.001

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Funding 

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Burnet Institute

    Monash University

      NIAID

        National Health and Medical Research Council (NHMRC) (2)