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Breastfeeding, maternal asthma and wheezing in the first year of life: a longitudinal birth cohort study.

Author information

Affiliations

  • 1. Dept of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada
      Authors
    • Azad MB 1
    (1 author)
  • 2. Dept of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada.
      Authors
    • Vehling L 2
    • Becker AB 2
    (2 authors)
  • 3. Dept of Pediatrics and Physiology, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
      Authors
    • Lu Z 3
    • Subbarao P 3
    (2 authors)
  • 4. Dept of Medicine, McMaster University, Hamilton, ON, Canada.
      Authors
    • Dai D 4
    • Lefebvre DL 4
    • Sears MR 4
    (3 authors)
  • 5. Dept of Pediatrics, University of Alberta, Edmonton, AB, Canada.
      Authors
    • Mandhane PJ 5
    (1 author)
    • Show all (6)

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The European Respiratory Journal, 01 May 2017, 49(5):1602019
https://doi.org/10.1183/13993003.02019-2016 PMID: 28461293 

A comment on this article appears in "Formula one: best is no formula." Eur Respir J. 2017 May 1;49(5):.

Abstract 

The impact of breastfeeding on respiratory health is uncertain, particularly when the mother has asthma. We examined the association of breastfeeding and wheezing in the first year of life.We studied 2773 infants from the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort. Caregivers reported on infant feeding and wheezing episodes at 3, 6 and 12 months. Breastfeeding was classified as exclusive, partial (supplemented with formula or complementary foods) or none.Overall, 21% of mothers had asthma, 46% breastfed for at least 12 months and 21% of infants experienced wheezing. Among mothers with asthma, breastfeeding was inversely associated with infant wheezing, independent of maternal smoking, education and other risk factors (adjusted rate ratio (aRR) 0.52; 95% CI 0.35-0.77 for ≥12 versus <6 months breastfeeding). Compared with no breastfeeding at 6 months, wheezing was reduced by 62% with exclusive breastfeeding (aRR 0.38; 95% CI 0.20-0.71) and by 37% with partial breastfeeding supplemented with complementary foods (aRR 0.63; 95% CI 0.43-0.93); however, breastfeeding was not significantly protective when supplemented with formula (aRR 0.89; 95% CI 0.61-1.30). Associations were not significant in the absence of maternal asthma (p-value for interaction <0.01).Breastfeeding appears to confer protection against wheezing in a dose-dependent manner among infants born to mothers with asthma.

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Read article at publisher's site: https://doi.org/10.1183/13993003.02019-2016

Read article for free, from open access legal sources, via Unpaywall: https://erj.ersjournals.com/content/erj/49/5/1602019.full.pdfUnpaywall

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    CIHR

      Canadian Institutes of Health Research

        Canadian Respiratory Research Network