Europe PMC

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Application of in-vitro screening methods on hypoxia inducible factor prolyl hydroxylase inhibitors.

Author information

Affiliations

  • 1. State Key Laboratory of Natural Medicines, and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.
      Authors
    • Wu Y 1
    • Jiang Z 1
    • You Q 1
    (3 authors)
  • 2. State Key Laboratory of Natural Medicines, and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China; Department of Organic Chemistry, School of Science, China Pharmaceutical University, Nanjing 210009, China.
      Authors
    • Zhang X 2
    (1 author)

ORCIDs linked to this article

Bioorganic & Medicinal Chemistry, 13 May 2017, 25(15):3891-3899
https://doi.org/10.1016/j.bmc.2017.05.026 PMID: 28625716 

Review

Abstract 

Anemia resulting from the reduced expression of erythropoietin (EPO) is a common complication of patients with chronic kidney diseases (CKD). Hypoxia inducible transcription factor-α (HIF-α), which adapts cellular hypoxia condition, regulates the expression of many downstream genes including the EPO gene. Hypoxia inducible transcription factor prolyl hydroxylase 2 (HIF-PHD2), as the key regulator of hypoxia response, is function of hydroxylating specify proline residues of HIF-α, which may lead to the degradation of HIF-α and eventually cause disenabling the expression of erythropoietin. Therefore, it is valid to improve anemia by inhibiting HIF-PHD2. In-vitro screening plays a vital role in searching for novel small molecule HIF-PHD2 inhibitors, thus, this review classified in-vitro screening methods which are used to hit novel HIF-PHD2 inhibitors.

Full text links 

Read article at publisher's site: https://doi.org/10.1016/j.bmc.2017.05.026

References 

Articles referenced by this article (47)

Show 10 more references (10 of 47)

Citations & impact 

Impact metrics

3
Citations
Jump to Citations

Citations of article over time

Alternative metrics

Altmetric item for https://www.altmetric.com/details/21222828
Altmetric
Discover the attention surrounding your research
https://www.altmetric.com/details/21222828

Smart citations by scite.ai
Smart citations by scite.ai include citation statements extracted from the full text of the citing article. The number of the statements may be higher than the number of citations provided by EuropePMC if one paper cites another multiple times or lower if scite has not yet processed some of the citing articles.
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1016/j.bmc.2017.05.026

Supporting
Mentioning
Contrasting
0
6
0

Article citations

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.

Funding 

Funders who supported this work.

National Major Science and Technology Project of China (1)

National Natural Science Foundation of China (3)

PAPD