Europe PMC

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Talk to your gut: the oral-gut microbiome axis and its immunomodulatory role in the etiology of rheumatoid arthritis.

Author information

Affiliations

  • 1. University of Groningen, University Medical Center Groningen, Department of Medical Microbiology, Hanzeplein 1, 9700 RB Groningen, the Netherlands.
      Authors
    • du Teil Espina M 1
    • Gabarrini G 1
    • Harmsen HJM 1
    • van Winkelhoff AJ 1
    • van Dijl JM 1
    (5 authors)
  • 2. University of Groningen, University Medical Center Groningen, Department of Rheumatology and Clinical Immunology, Hanzeplein 1, 9700 RB Groningen, the Netherlands.
      Authors
    • Westra J 2
    (1 author)

ORCIDs linked to this article

FEMS Microbiology Reviews, 01 Jan 2019, 43(1):1-18
https://doi.org/10.1093/femsre/fuy035 PMID: 30219863 

Review

Abstract 

Microbial communities inhabiting the human body, collectively called the microbiome, are critical modulators of immunity. This notion is underpinned by associations between changes in the microbiome and particular autoimmune disorders. Specifically, in rheumatoid arthritis, one of the most frequently occurring autoimmune disorders worldwide, changes in the oral and gut microbiomes have been implicated in the loss of tolerance against self-antigens and in increased inflammatory events promoting the damage of joints. In the present review, we highlight recently gained insights in the roles of microbes in the etiology of rheumatoid arthritis. In addition, we address important immunomodulatory processes, including biofilm formation and neutrophil function, which have been implicated in host-microbe interactions relevant for rheumatoid arthritis. Lastly, we present recent advances in the development and evaluation of emerging microbiome-based therapeutic approaches. Altogether, we conclude that the key to uncovering the etiopathogenesis of rheumatoid arthritis will lie in the immunomodulatory functions of the oral and gut microbiomes.

Full text links 

Read article at publisher's site: https://doi.org/10.1093/femsre/fuy035

Read article for free, from open access legal sources, via Unpaywall: https://academic.oup.com/femsre/article-pdf/43/1/1/27202540/fuy035.pdfUnpaywall

References 

Articles referenced by this article (199)

Show 10 more references (10 of 199)

Citations & impact 

Impact metrics

58
Citations
Jump to Citations

Citations of article over time

Alternative metrics

Altmetric item for https://www.altmetric.com/details/48514288
Altmetric
Discover the attention surrounding your research
https://www.altmetric.com/details/48514288

Smart citations by scite.ai
Smart citations by scite.ai include citation statements extracted from the full text of the citing article. The number of the statements may be higher than the number of citations provided by EuropePMC if one paper cites another multiple times or lower if scite has not yet processed some of the citing articles.
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1093/femsre/fuy035

Supporting
Mentioning
Contrasting
2
70
0

Article citations

Go to all (58) article citations

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.

Funding 

Funders who supported this work.

University Medical Center Groningen

    University of Groningen