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A Subset of Type I Conventional Dendritic Cells Controls Cutaneous Bacterial Infections through VEGFα-Mediated Recruitment of Neutrophils.

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Affiliations

  • 1. Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A(∗)STAR), 8A Biomedical Grove, Biopolis, Singapore 138648, Singapore; Skin Research Institute of Singapore (SRIS), Agency for Science, Technology and Research (A(∗)STAR), 11 Mandalay Rd., Singapore 308232, Singapore.
      Authors
    • Janela B 1
    • Ginhoux F 1
    (2 authors)
  • 2. Division of Medicine, University College London, University of London, London WC1E 6BT, England, UK.
      Authors
    • Patel AA 2
    • Maini AA 2
    • Yona S 2
    (3 authors)
  • 3. Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A(∗)STAR), 8A Biomedical Grove, Biopolis, Singapore 138648, Singapore.
      Authors
    • Lau MC 3
    • Goh CC 3
    • Msallam R 3
    • Kong WT 3
    • Fehlings M 3
    • Hubert S 3
    • Lum J 3
    • Simoni Y 3
    • Chen J 3
    • Poidinger M 3
    • Newell E 3
    • Ng LG 3
    (12 authors)
  • 4. Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A(∗)STAR), 8A Biomedical Grove, Biopolis, Singapore 138648, Singapore; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545, Singapore.
      Authors
    • Malleret B 4
    (1 author)
  • 5. Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A(∗)STAR), 8A Biomedical Grove, Biopolis, Singapore 138648, Singapore; Nestlé Skin Health R&D/GALDERMA, La Tour-de-Peilz 1814, Switzerland.
      Authors
    • Zolezzi F 5
    (1 author)
    • Show all (12)

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Immunity, 27 Mar 2019, 50(4):1069-1083.e8
https://doi.org/10.1016/j.immuni.2019.03.001 PMID: 30926233 

A comment on this article appears in "cDC1s: New Orchestrators of Tissue Innate Immunity." Trends Immunol. 2019 Jul;40(7):559-561.

Abstract 

Skin conventional dendritic cells (cDCs) exist as two distinct subsets, cDC1s and cDC2s, which maintain the balance of immunity to pathogens and tolerance to self and microbiota. Here, we examined the roles of dermal cDC1s and cDC2s during bacterial infection, notably Propionibacterium acnes (P. acnes). cDC1s, but not cDC2s, regulated the magnitude of the immune response to P. acnes in the murine dermis by controlling neutrophil recruitment to the inflamed site and survival and function therein. Single-cell mRNA sequencing revealed that this regulation relied on secretion of the cytokine vascular endothelial growth factor α (VEGF-α) by a minor subset of activated EpCAM+CD59+Ly-6D+ cDC1s. Neutrophil recruitment by dermal cDC1s was also observed during S. aureus, bacillus Calmette-Guérin (BCG), or E. coli infection, as well as in a model of bacterial insult in human skin. Thus, skin cDC1s are essential regulators of the innate response in cutaneous immunity and have roles beyond classical antigen presentation.

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Read article at publisher's site: https://doi.org/10.1016/j.immuni.2019.03.001

Read article for free, from open access legal sources, via Unpaywall: http://www.cell.com/article/S1074761319300913/pdfUnpaywall

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Funding 

Funders who supported this work.

BMRC (1)

Biomedical Research Council Industry Alignment Fund (1)

DCBiol Labex (2)

NIAID NIH HHS (1)

Nestlé Skin Health R&D/GALDERMA

    PHENOMIN

      SIgN Immunomonitoring platform

        Singapore Immunology Network