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Tumor-associated macrophages: role in cancer development and therapeutic implications.

Author information

Affiliations

  • 1. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
      Authors
    • Salmaninejad A 1, 3
    (1 author)
  • 2. Medical Genetics Network (MeGeNe), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
      Authors
    • Valilou SF 2
    (1 author)
  • 3. Medical Genetics Research Center, Student Research Committee, Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
      Authors
    • Salmaninejad A 1, 3
    • Soltani A 3
    • Abarghan YJ 3
    (3 authors)
  • 4. Student Research Committee, Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
      Authors
    • Ahmadi S 4
    (1 author)
  • 5. Department of Pharmacology and Toxicology, University of Otago, Dunedin, New Zealand.
      Authors
    • Rosengren RJ 5
    (1 author)
    • Show all (6)

ORCIDs linked to this article

Cellular Oncology (Dordrecht, Netherlands), 29 May 2019, 42(5):591-608
https://doi.org/10.1007/s13402-019-00453-z PMID: 31144271 

Review

Abstract 

Background

Tumor-associated macrophages (TAMs) are known to play important roles in the initiation and progression of human cancers, as well as in angiogenesis. TAMs are considered as main components of the tumor microenvironment. Targeting TAMs may serve as a therapeutic strategy for the treatment of cancer. In this review, the signaling pathways, origin, function, polarization and clinical application of TAMs are discussed. The role of TAMs in tumor initiation, progression, angiogenesis, invasion and metastasis are also emphasized. In addition, a variety of clinical and pre-clinical approaches to target TAMs are discussed.

Conclusions

Clinical therapeutic approaches that show most promise include blocking the extravasation of TAMs along with using TAMs as diagnostic biomarkers for cancer progression. The targeting of TAMs in a variety of clinical settings appears to be a promising strategy for decreasing metastasis formation and for improving patient outcome.

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Read article at publisher's site: https://doi.org/10.1007/s13402-019-00453-z

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