RNA polymerase II of Drosophila. Relation of its 140,000 Mr subunit to the beta subunit of Escherichia coli RNA polymerase.

Falkenburg D; Dworniczak B; Faust DM; Bautz EK

doi:10.1016/0022-2836(87)90496-7

RNA polymerase II of Drosophila. Relation of its 140,000 Mr subunit to the beta subunit of Escherichia coli RNA polymerase.

Affiliations

1. Institut für Molekulare Genetik d. Universität, Heidelberg, Germany.
Authors
Falkenburg D¹
(1 author)

Journal of Molecular Biology, 01 Jun 1987, 195(4):929-937
https://doi.org/10.1016/0022-2836(87)90496-7 PMID: 3116266

Abstract

We have determined the nucleotide sequence of the gene coding for the 140,000 Mr subunit of the DNA-dependent RNA polymerase II from Drosophila melanogaster. This analysis revealed features that are typical for a household-function gene. The codon usage is relaxed and there is no apparent TATA box upstream from the transcription start site. A comparison of the deduced amino acid sequence with that of the Escherichia coli RNA polymerase beta subunit shows a total of nine regions of homology. These regions are also conserved in chloroplast DNA of tobacco. This supports the notion that the two large subunits of the eukaryotic RNA polymerases are the structural and functional equivalents of E. coli beta' and beta subunits.

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References

Articles referenced by this article (35)

Extensive homology among the largest subunits of eukaryotic and prokaryotic RNA polymerases.
Allison LA, Moyle M, Shales M, Ingles CJ
Cell, (2):599-610 1985
MED: 3896517
Codon selection in yeast.
Bennetzen JL, Hall BD
J Biol Chem, (6):3026-3031 1982
MED: 7037777
Screening lambdagt recombinant clones by hybridization to single plaques in situ.
Benton WD, Davis RW
Science, (4286):180-182 1977
MED: 322279
Title not supplied
Biggin
1983
Structure of the eukaryotic transcription apparatus: features of the gene for the largest subunit of Drosophila RNA polymerase II.
Biggs J, Searles LL, Greenleaf AL
Cell, (2):611-621 1985
MED: 2992806
Eukaryotic nuclear RNA polymerases.
Chambon P
Annu Rev Biochem, 613-638 1975
MED: 1094919
The gene encoding the large subunit of human RNA polymerase II.
Cho KW, Khalili K, Zandomeni R, Weinmann R
J Biol Chem, (28):15204-15210 1985
MED: 2999107
Empirical predictions of protein conformation.
Chou PY, Fasman GD
Annu Rev Biochem, 251-276 1978
MED: 354496
Title not supplied
Ciliberto
Curr. Top. Devel. Biol 1983
Title not supplied
Corden
1985

Show 10 more references (10 of 35)

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GlyGen is an international glycobioinformatics knowledgebase funded by The National Institutes of Health to facilitate glycoscience research by integrating diverse kinds of information, including glycomics, genomics, proteomics (and glycoproteomics), cell biology, developmental biology and biochemistry.

https://www.glygen.org/publication/MED/3116266

Nucleotide sequences in ENA (2)

Drosophila melanogaster (fruit fly) RNA polymerase(ENA - CAA29180)
Drosophila DmRP140 gene for RNA polymerase II 140,000 M(r)subunit(ENA - X05709)

Protein families in InterPro

RNA_pol_bsu_protrusion(InterPro - IPR007644)

Search life-sciences literature (45,105,671 articles, preprints and more)

RNA polymerase II of Drosophila. Relation of its 140,000 Mr subunit to the beta subunit of Escherichia coli RNA polymerase.

Affiliations

Authors

Abstract

Full text links

References

Extensive homology among the largest subunits of eukaryotic and prokaryotic RNA polymerases.

Codon selection in yeast.

Screening lambdagt recombinant clones by hybridization to single plaques in situ.

Title not supplied

Structure of the eukaryotic transcription apparatus: features of the gene for the largest subunit of Drosophila RNA polymerase II.

Eukaryotic nuclear RNA polymerases.

The gene encoding the large subunit of human RNA polymerase II.

Empirical predictions of protein conformation.

Title not supplied

Title not supplied

Citations & impact

Impact metrics

Citations of article over time

Article citations

In silico identification of Drosophila melanogaster genes encoding RNA polymerase subunits.

Gene silencing in Tribolium castaneum as a tool for the targeted identification of candidate RNAi targets in crop pests.

Chronic and acute alterations in the functional levels of Frequenins 1 and 2 reveal their roles in synaptic transmission and axon terminal morphology.

Tachykinin-related peptides modulate odor perception and locomotor activity in Drosophila.

Detection of parallel functional modules by comparative analysis of genome sequences.

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FlyBase

Gene Ontology Annotation Project

Proteins in UniProt (2)

Nucleotide sequences in ENA (2)

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Search life-sciences literature (45,105,671 articles, preprints and more)

RNA polymerase II of Drosophila. Relation of its 140,000 Mr subunit to the beta subunit of Escherichia coli RNA polymerase.

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