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Circulating biomarkers for early detection and clinical management of colorectal cancer.

Author information

Affiliations

  • 1. Gastrointestinal & Pancreatic Oncology Group, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD) / Hospital Clínic of Barcelona/ Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.
      Authors
    • Marcuello M 1
    • Duran-Sanchon S 1
    • Castells A 1
    • Gironella M 1
    (4 authors)
  • 2. Institute of Experimental Medicine of the Czech Academy of Sciences and Institute of Biology and Medical Genetics, First Medical Faculty, Charles University, Prague, Czech Republic.
      Authors
    • Vymetalkova V 2
    • Vodicka P 2
    (2 authors)
  • 3. Experimental Surgical Oncology, General, Visceral and Pediatric Surgery, University Hospital and Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
      Authors
    • Neves RPL 3
    • van Dalum G 3
    • Flügen G 3
    • Stoecklein NH 3
    (4 authors)
  • 4. Department of Molecular Oncology, Institute for Cancer Research, K.G. Jebsen Colorectal Cancer Research Centre, Oslo University Hospital-Norwegian Radium Hospital, Oslo, Norway.
      Authors
    • Vedeld HM 4
    • Lind GE 4
    (2 authors)
  • 5. Department of Clinical Genetics, Karolinska University Hospital and Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
      Authors
    • Tham E 5
    (1 author)
    • Show all (8)

ORCIDs linked to this article

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Molecular Aspects of Medicine, 14 Jun 2019, 69:107-122
https://doi.org/10.1016/j.mam.2019.06.002 PMID: 31189073 

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Abstract 

New non-invasive approaches that can complement and improve on current strategies for colorectal cancer (CRC) screening and management are urgently needed. A growing number of publications have documented that components of tumors, which are shed into the circulation, can be detected in the form of liquid biopsies and can be used to detect CRC at early stages, to predict response to certain therapies and to detect CRC recurrence in a minimally invasive way. The analysis of circulating tumor DNA (ctDNA), tumor-derived cells (CTC, circulating tumor cells) or circulating microRNA (miRNA) in blood and other body fluids, have a great potential to improve different aspects of CRC management. The challenge now is to find which types of components, biofluids and detection methods would be the most suitable to be applied in the different steps of CRC detection and treatment. This chapter will provide an up to date review on ctDNA, CTCs and circulating miRNAs as new biomarkers for CRC, either for clinical management or early detection, highlighting their advantages and limitations.

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Read article at publisher's site: https://doi.org/10.1016/j.mam.2019.06.002

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Funding 

Funders who supported this work.

CERCA Programme/Generalitat de Catalunya, Spain

    COST (European Cooperation in Science and Technology

      Christian Doppler Laboratory for Liquid Biopsies for early Detection of Cancer, Austria

        Dutch Cancer Society

          FEDER-European Union

            Fundación Científica de la Asociación Española contra el Cáncer (1)

            Instituto de Salud Carlos III (1)

            Instituto de Salud Carlos III, Spain

              Ministerio de Economía y Competitividad (2)

              Ministry of Health of the Czech Republic (2)

              SGR_653

                Stockholm County Council

                  Swedish Childhood Cancer Fund