Antibodies to the capsular polysaccharide of Neisseria meningitidis group B or E. coli K1 bind to the brains of infant rats in vitro but not in vivo.

Saukkonen K; Haltia M; Frosch M; Bitter-Süerman D; Leinonen M

doi:10.1016/0882-4010(86)90036-7

Antibodies to the capsular polysaccharide of Neisseria meningitidis group B or E. coli K1 bind to the brains of infant rats in vitro but not in vivo.

Affiliations

1. Medical Council, Academy of Finland, Helsinki.
Authors
Saukkonen K¹
(1 author)

Microbial Pathogenesis, 01 Feb 1986, 1(1):101-105
https://doi.org/10.1016/0882-4010(86)90036-7 PMID: 3150023

Abstract

The binding of monoclonal and polyclonal IgG antibodies specific to the capsular polysaccharide of Neisseria meningitidis group B and E. coli K1 was tested to the cross-reacting polysialosyl structures previously shown to be present in the brain of infant rats (Lancet 1983; ii: 355-7). Strong immunofluorescence was obtained after in vitro incubation of the brains of 1 to 13 days old rats with the antibodies whereas the brains of adult rats remained negative. The number of antibody-binding structures decreased as a function of age, being highest at the age of 1 to 5 days. However, when the same antibodies were injected intraperitoneally into the infant rat, or into the mother rat 2 days before parturition, no binding of antibodies to the infant rat brain tissue was observed.

Full text links

Read article at publisher's site: https://doi.org/10.1016/0882-4010(86)90036-7

References

Articles referenced by this article (19)

Immunochemical similarity between polysaccharide antigens of Escherichia coli 07: K1(L):NM and group B Neisseria meningitidis.
Kasper DL, Winkelhake JL, Zollinger WD, Brandt BL, Artenstein MS
J Immunol, (1):262-268 1973
MED: 4346607
Immunologic response of man to group B meningococcal polysaccharide vaccines.
Wyle FA, Artenstein MS, Brandt BL, Tramont EC, Kasper DL, Altieri PL, Berman SL, Lowenthal JP
J Infect Dis, (5):514-521 1972
MED: 4197754
Immunochemistry of groups A, B, and C meningococcal polysaccharide-tetanus toxoid conjugates
Jennings
J Immunol 1982
Class-specific antibody response to group B Neisseria meningitidis capsular polysaccharide: use of polylysine precoating in an enzyme-linked immunosorbent assay.
Leinonen M, Frasch CE
Infect Immun, (3):1203-1207 1982
MED: 6818147
Enhancement of immunologic activity by noncovalent complexing of meningococcal group B polysaccharide and outer membrane proteins
Zollinger
1982
Immunity and protection of mice against Neisseria meningitidis group B by vaccination, using polysaccharide complexed with outer membrane proteins: a comparison with purified B polysaccharide.
Moreno C, Lifely MR, Esdaile J
Infect Immun, (2):527-533 1985
MED: 3917979
Antigenic similarities between brain components and bacteria causing meningitis. Implications for vaccine development and pathogenesis.
Finne J, Leinonen M, Makela PH
Lancet, (8346):355-357 1983
MED: 6135869
Cleavage of the polysialosyl units of brain glycoproteins by a bacteriophage endosialidase. Involvement of a long oligosaccharide segment in molecular interactions of polysialic acid.
Finne J, Makela PH
J Biol Chem, (2):1265-1270 1985
MED: 3968060
The Escherichia coli K1 capsule shares antigenic determinants with the human gangliosides GM3 and GD3.
Soderstrom T, Hansson G, Larson G
N Engl J Med, (11):726-727 1984
MED: 6199668
Levels of plasma proteins in human and rat fetal CSF and the development of the blood-CSF barrier
Adinolfi
Neuropaediatrics 1977

Show 9 more references (10 of 19)

Citations & impact

Impact metrics

Citations

Jump to Citations

Citations of article over time

Alternative metrics

Altmetric item for https://www.altmetric.com/details/42103967

Altmetric
Discover the attention surrounding your research
https://www.altmetric.com/details/42103967

Article citations

The β-reducing end in α(2-8)-polysialic acid constitutes a unique structural motif.
Azurmendi HF, Battistel MD, Zarb J, Lichaa F, Negrete Virgen A, Shiloach J, Freedberg DI
Glycobiology, 27(9):900-911, 01 Sep 2017
Cited by: 6 articles | PMID: 28369425 | PMCID: PMC6283323
Free full text in Europe PMC
Capsular polysaccharide vaccine for Group B Neisseria meningitidis, Escherichia coli K1, and Pasteurella haemolytica A2.
Robbins JB, Schneerson R, Xie G, Hanson LÅ, Miller MA
Proc Natl Acad Sci U S A, 108(44):17871-17875, 24 Oct 2011
Cited by: 19 articles | PMID: 22025709 | PMCID: PMC3207679
Free full text in Europe PMC
Extracellular structure of polysialic acid explored by on cell solution NMR.
Azurmendi HF, Vionnet J, Wrightson L, Trinh LB, Shiloach J, Freedberg DI
Proc Natl Acad Sci U S A, 104(28):11557-11561, 03 Jul 2007
Cited by: 25 articles | PMID: 17609375 | PMCID: PMC1906721
Free full text in Europe PMC
Neisseria meningitidis group B correlates of protection and assay standardization--international meeting report Emory University, Atlanta, Georgia, United States, 16-17 March 2005.
Borrow R, Carlone GM, Rosenstein N, Blake M, Feavers I, Martin D, Zollinger W, Robbins J, Aaberge I, Granoff DM, Miller E, Plikaytis B, van Alphen L, Poolman J, Rappuoli R, Danzig L, Hackell J, Danve B, Caulfield M, [...] Stephens D
Vaccine, 24(24):5093-5107, 01 Jun 2006
Cited by: 125 articles | PMID: 16838413
Are antibodies to the capsular polysaccharide of Neisseria meningitidis group B and Escherichia coli K1 associated with immunopathology?
Stein DM, Robbins J, Miller MA, Lin FY, Schneerson R
Vaccine, 24(3):221-228, 11 Aug 2005
Cited by: 28 articles | PMID: 16125824
Review

Go to all (10) article citations

Search life-sciences literature (45,105,671 articles, preprints and more)

Antibodies to the capsular polysaccharide of Neisseria meningitidis group B or E. coli K1 bind to the brains of infant rats in vitro but not in vivo.

Affiliations

Authors

Abstract

Full text links

References

Immunochemical similarity between polysaccharide antigens of Escherichia coli 07: K1(L):NM and group B Neisseria meningitidis.

Immunologic response of man to group B meningococcal polysaccharide vaccines.

Immunochemistry of groups A, B, and C meningococcal polysaccharide-tetanus toxoid conjugates

Class-specific antibody response to group B Neisseria meningitidis capsular polysaccharide: use of polylysine precoating in an enzyme-linked immunosorbent assay.

Enhancement of immunologic activity by noncovalent complexing of meningococcal group B polysaccharide and outer membrane proteins

Immunity and protection of mice against Neisseria meningitidis group B by vaccination, using polysaccharide complexed with outer membrane proteins: a comparison with purified B polysaccharide.

Antigenic similarities between brain components and bacteria causing meningitis. Implications for vaccine development and pathogenesis.

Cleavage of the polysialosyl units of brain glycoproteins by a bacteriophage endosialidase. Involvement of a long oligosaccharide segment in molecular interactions of polysialic acid.

The Escherichia coli K1 capsule shares antigenic determinants with the human gangliosides GM3 and GD3.

Levels of plasma proteins in human and rat fetal CSF and the development of the blood-CSF barrier

Citations & impact

Impact metrics

Citations of article over time

Alternative metrics

Article citations

The β-reducing end in α(2-8)-polysialic acid constitutes a unique structural motif.

Capsular polysaccharide vaccine for Group B Neisseria meningitidis, Escherichia coli K1, and Pasteurella haemolytica A2.

Extracellular structure of polysialic acid explored by on cell solution NMR.

Neisseria meningitidis group B correlates of protection and assay standardization--international meeting report Emory University, Atlanta, Georgia, United States, 16-17 March 2005.

Are antibodies to the capsular polysaccharide of Neisseria meningitidis group B and Escherichia coli K1 associated with immunopathology?

Similar Articles

Antigenic similarities between brain components and bacteria causing meningitis. Implications for vaccine development and pathogenesis.

Bactericidal activity of two IgG2a murine monoclonal antibodies with distinct fine specificities for group B Neisseria meningitidis capsular polysaccharide.

A human monoclonal macroglobulin with specificity for alpha(2----8)-linked poly-N-acetyl neuraminic acid, the capsular polysaccharide of group B meningococci and Escherichia coli K1, which crossreacts with polynucleotides and with denatured DNA.

The capsular polysaccharide of group B Neisseria meningitidis as a vehicle for vaccine development.

Partnerships & funding

Similar Articles

Antigenic similarities between brain components and bacteria causing meningitis. Implications for vaccine development and pathogenesis.
Lancet, 2(8346):355-357, 01 Aug 1983

Bactericidal activity of two IgG2a murine monoclonal antibodies with distinct fine specificities for group B Neisseria meningitidis capsular polysaccharide.
Hybridoma, 11(6):677-687, 01 Dec 1992

A human monoclonal macroglobulin with specificity for alpha(2----8)-linked poly-N-acetyl neuraminic acid, the capsular polysaccharide of group B meningococci and Escherichia coli K1, which crossreacts with polynucleotides and with denatured DNA.

The capsular polysaccharide of group B Neisseria meningitidis as a vehicle for vaccine development.
Contrib Microbiol Immunol, 10:151-165, 01 Jan 1989

Search life-sciences literature (45,105,671 articles, preprints and more)

Antibodies to the capsular polysaccharide of Neisseria meningitidis group B or E. coli K1 bind to the brains of infant rats in vitro but not in vivo.

Author information

Affiliations

Authors

Abstract

Full text links

References

Immunochemistry of groups A, B, and C meningococcal polysaccharide-tetanus toxoid conjugates

Enhancement of immunologic activity by noncovalent complexing of meningococcal group B polysaccharide and outer membrane proteins

Levels of plasma proteins in human and rat fetal CSF and the development of the blood-CSF barrier

Citations & impact

Impact metrics

Citations of article over time

Alternative metrics

Article citations

Similar Articles

Partnerships & funding