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Seroprevalence of yellow fever, dengue, West Nile and chikungunya viruses in children in Teso South Sub-County, Western Kenya.

Author information

Affiliations

  • 1. Centre for Virus Research, Kenya Medical Research Institute, Nairobi, Kenya.
      Authors
    • Inziani M 1
    • Awando J 1
    • Kihoro R 1
    (3 authors)
  • 2. Centre for Infectious and Parasitic Diseases Control Research (CIPDCR), Kenya Medical Research Institute, Busia, Kenya.
      Authors
    • Adungo F 2
    • Mwau M 2
    (2 authors)
  • 3. Nagasaki University Africa Research Station, Nairobi, Kenya.
      Authors
    • Inoue S 3
    (1 author)
  • 4. Nagasaki University Institute of Tropical Medicine, Nagasaki, Japan.
      Authors
    • Morita K 4
    (1 author)
  • 5. Department of Paediatrics and Child Health, University of Nairobi, Nairobi, Kenya.
      Authors
    • Obimbo E 5
    • Onyango F 5
    (2 authors)

ORCIDs linked to this article

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases, 08 Nov 2019, 91:104-110
https://doi.org/10.1016/j.ijid.2019.11.004 PMID: 31712089 

Abstract 

Background

Arboviruses often cause widespread morbidity in children in endemic regions. Data on the burden of arboviruses in Kenyan children are limited.

Objectives

This study was performed to determine the seroprevalence of yellow fever (YFV), dengue (DENV), West Nile (WNV), and chikungunya (CHIKV) viruses among children 1-12 years of age at two health facilities in Teso South Sub-County in Western Kenya.

Methods

In a hospital-based cross-sectional survey, a questionnaire was used to collect socio-demographic information. Serum drawn from the children was tested for IgA/IgM/IgG serocomplex antibodies to selected arboviruses using indirect ELISA and plaque reduction neutralization tests.

Results

A total of 182 (27.7%) of the 656 participants tested were positive for any arbovirus antibody. Of these, 4.4% (29/656) tested positive for YFV, 9.6% (62/649) for WNV, 5.6% (36/649) for CHIKV, 1.4% (5/368) for DENV1, 9% (59/656) for DENV2, and 19.7% (40/203) for DENV3. Neutralizing antibodies to CHIKV were found in 77.8% (42/54) of participants, to YFV in 15.8% (3/19), to DENV2 in 58% (29/50), and to WNV in 8% (1/55). Sex, age, urban residence, schooling, and lack of vaccination were associated with arbovirus exposure.

Conclusions

This study confirmed that children under 12 years of age in Teso South Sub-County are exposed to ongoing arbovirus infections early in life.

Full text links 

Read article at publisher's site: https://doi.org/10.1016/j.ijid.2019.11.004

Read article for free, from open access legal sources, via Unpaywall: http://www.ijidonline.com/article/S1201971219304436/pdfUnpaywall

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Funding 

Funders who supported this work.

Japan and Kenya Medical Research Institute

    Nagasaki

      Nagasaki University Institute of Tropical Medicine

        Nairobi Kenya

          The Department of Virology