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Molecular profiling of thymoma with myasthenia gravis: Risk factors of developing myasthenia gravis in thymoma patients.

Author information

Affiliations

  • 1. Division of Thoracic Surgery, Department of Surgery, Taichung Veteran General Hospital, Taichung, 40705, Taiwan; Institute of Clinical Medicine, National Yang-Ming University, Taipei, 11221, Taiwan.
      Authors
    • Lee MC 1
    (1 author)
  • 2. Department of Medical Research, Taichung Veterans General Hospital, Taichung 40705, Taiwan; Department of Public Health, Fu Jen Catholic University, New Taipei City, 24205, Taiwan; Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung, 40227, Taiwan.
      Authors
    • Hsiao TH 2
    (1 author)
  • 3. Department of Medical Research, Taichung Veterans General Hospital, Taichung 40705, Taiwan.
      Authors
    • Chuang HN 3
    • Tsai HM 3
    • Mao CL 3
    (3 authors)
  • 4. Division of Thoracic Surgery, Department of Surgery, Taichung Veteran General Hospital, Taichung, 40705, Taiwan.
      Authors
    • Lee LW 4
    (1 author)
  • 5. Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, 81362, Taiwan; Department of Pathology and Laboratory Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, 81362, Taiwan.
      Authors
    • Chi PL 5
    (1 author)
    • Show all (6)

ORCIDs linked to this article

Lung Cancer (Amsterdam, Netherlands), 15 Nov 2019, 139:157-164
https://doi.org/10.1016/j.lungcan.2019.11.007 PMID: 31809976 

Abstract 

Objective

Thymoma is a rare epithelial tumor arising from the thymus in the anterior mediastinum. Nearly 50% of patients with thymoma develop myasthenia gravis, which is an indication of a poor long-term prognosis. Here, we identified specific and effective molecular markers for predicting in the development of myasthenia gravis patients with thymoma.

Material and methods

We investigated molecular profiling based on RNA-sequencing (RNA-seq) for myasthenia gravis development in patients with thymoma. RNA was extracted from 34 patients with thymoma, 16 of whom had myasthenic and 18 of whom did not, and transcriptome profiles were analyzed through next-generation sequencing.

Results

We discovered 140 differential expressed genes associated with myasthenia gravis in thymoma patients. The four genes, hypoxia-inducible factor 3 alpha (HIF3A), insulin-like growth factor-binding protein 1, pyruvate dehydrogenase kinase, and Krüppel-like factor 15 were differentially expressed in patients with thymoma who has myasthenia gravis and were validated by quantitative polymerase chain reaction. HIF3A expression was significantly higher in patients with myasthenia gravis than in those without.

Conclusion

HIF3A is aberrantly expressed in patient with thymoma who has myasthenia gravis and may be involved in the development of myasthenia gravis in thymoma patient.

Full text links 

Read article at publisher's site: https://doi.org/10.1016/j.lungcan.2019.11.007

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Funding 

Funders who supported this work.

Ministry of Science and Technology, Taiwan (2)

Taichung Veterans General Hospital and Taichung Veterans General Hospital Chiayi Branch Joint Research Program (1)