Europe PMC

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Large and small platelets-(When) do they differ?

Author information

Affiliations

  • 1. Institut für Immunologie und Transfusionsmedizin, Abteilung Transfusionsmedizin, Universitätsmedizin Greifswald, Greifswald, Germany.
      Authors
    • Handtke S 1
    • Thiele T 1
    (2 authors)

ORCIDs linked to this article

Journal of Thrombosis and Haemostasis : JTH, 09 Apr 2020, 18(6):1256-1267
https://doi.org/10.1111/jth.14788 PMID: 32108994 

Review

Abstract 

Platelets are most important in providing cellular hemostasis but also take part in inflammation and immune processes. Increased platelet size has been regarded as a feature describing a young and more reactive subpopulation until studies were published which questioned this concept. Moreover, changes of platelet size given by the mean platelet volume (MPV) were described for immune thrombocytopenia, cardiovascular disease, atherosclerosis, venous thromboembolism, chronic lung disease, sepsis, cancer-associated thrombosis, autoimmune disorders, and others. This review summarizes the literature on what is known about platelets with different size and describes controversies of studies with large and small platelets putting a focus on their thrombogenicity, age, and on the association of MPV with the mentioned diseases.

Full text links 

Read article at publisher's site: https://doi.org/10.1111/jth.14788

Read article for free, from open access legal sources, via Unpaywall: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jth.14788Unpaywall

Citations & impact 

Impact metrics

37
Citations
Jump to Citations

Citations of article over time

Alternative metrics

Altmetric item for https://www.altmetric.com/details/135532556
Altmetric
Discover the attention surrounding your research
https://www.altmetric.com/details/135532556

Smart citations by scite.ai
Smart citations by scite.ai include citation statements extracted from the full text of the citing article. The number of the statements may be higher than the number of citations provided by EuropePMC if one paper cites another multiple times or lower if scite has not yet processed some of the citing articles.
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1111/jth.14788

Supporting
Mentioning
Contrasting
1
65
0

Article citations

Go to all (37) article citations

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.