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Three-step two-pot automated production of NCA [18F]FDOPA with FlexLab module.

Author information

Affiliations

  • 1. PET Center, Department of Nuclear Medicine, National Taiwan University Hospital, 7, Chung-Shan S. Road, Taipei, 100, Taiwan.
      Authors
    • Huang YY 1
    • Tsai CL 1
    (2 authors)
  • 2. Department of Molecular Imaging and Therapy, Austin Health, 145 Studley Road, Heidelberg, Victoria, 3084, Australia; iPHASE Technologies, 3 Cypress Ave, Glen Waverley, Victoria, 3150, Australia.
      Authors
    • Poniger S 2
    • Tochon-Danguy HJ 2
    (2 authors)
  • 3. Department of Molecular Imaging and Therapy, Austin Health, 145 Studley Road, Heidelberg, Victoria, 3084, Australia.
      Authors
    • Ackermann U 3
    (1 author)
  • 4. PET Center, Department of Nuclear Medicine, National Taiwan University Hospital, 7, Chung-Shan S. Road, Taipei, 100, Taiwan; Molecular Imaging Center, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, 106, Taiwan.
      Authors
    • Yen RF 4
    (1 author)

ORCIDs linked to this article

Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for use in Agriculture, Industry and Medicine, 22 Aug 2019, 158:108871
https://doi.org/10.1016/j.apradiso.2019.108871 PMID: 32113705 

Abstract 

Automated three-step two-pot production of no-carrier-added (NCA) [18F]FDOPA was first implemented in the iPHASE FlexLab module. Decay-corrected radiochemical yield (RCY) of [18F]FDOPA synthesized by this method was 10~14% (n = 7) with a synthesis time of ~110 min [18F]FDOPA was obtained in > 95% of radiochemical purity with a molar activity of ~431 GBq/μmol. With the method successfully implementing on the commercial FlexLab module and its built-in step-by-step activity monitoring, further processes optimization would be achieved.

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Read article at publisher's site: https://doi.org/10.1016/j.apradiso.2019.108871

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Funding 

Funders who supported this work.

Ministry of Science and Technology of Taiwan (1)

National Taiwan University Hospital (2)