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Isorhamnetin: A review of pharmacological effects.

Author information

Affiliations

  • 1. Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, PR China.
      Authors
    • Gong G 1
    • Zhang H 1
    (2 authors)
  • 2. Department of Pharmacy, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.
      Authors
    • Guan YY 2
    (1 author)
  • 3. Department of Pharmacology, School of Pharmacy, Chengdu Medical College, Chengdu, PR China.
      Authors
    • Zhang ZL 3
    (1 author)
  • 4. School of Pharmacy and Biomolecular Sciences, Faculty of Science, Liverpool John Moores University, Liverpool, L3 3AF, England, UK.
      Authors
    • Rahman K 4
    (1 author)
  • 5. Department of Drug Preparation, Hospital of TCM and Hui Nationality Medicine, Ningxia Medical University, Wuzhong, PR China.
      Authors
    • Wang SJ 5
    (1 author)
    • Show all (7)

ORCIDs linked to this article

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 02 Jun 2020, 128:110301
https://doi.org/10.1016/j.biopha.2020.110301 PMID: 32502837 

Review

Abstract 

Isorhamnetin is one of the most important active ingredients in the fruits of Hippophae rhamnoides L. and the leaves of Ginkgo biloba L., which possesses extensive pharmacological activities. At present, there have been numerous investigations on isorhamnetin, which has the effects of cardiovascular and cerebrovascular protection, anti-tumor, anti-inflammatory, anti-oxidation, organ protection, prevention of obesity, etc. The related mechanisms involve the regulation of PI3K/AKT/PKB, NF-κB, MAPK and other signaling pathways as well as the expression of related cytokines and kinases. Isorhamnetin has a high value of development and application. However, the investigations on its mechanism of action are limited and lack of detailed scientific validation. The manuscript reviewed the pharmacological effects of isorhamnetin and related mechanisms of action for the development of its medicinal properties further.

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Read article at publisher's site: https://doi.org/10.1016/j.biopha.2020.110301

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Funding 

Funders who supported this work.

National Key Subject of Drug Innovation (1)

National Natural Science Foundation of China (2)

National key R & D program for key research project of modernization of traditional Chinese medicine (1)

Ruijin Youth NSFC Cultivation Fund (1)

Science and Technology Commission of Shanghai Municipality

    Shanghai Institutions of Higher Learning, Shanghai “Chenguang Program” of Education Commission of Shanghai Municipality (1)

    • Grant ID: 18CG46

      0 publications

    “Yangfan Program” (1)

    • Grant ID: 19YF1449400

      0 publications