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Photodynamic therapy for prostate cancer - A narrative review.

Author information

Affiliations

  • 1. Department of Photomorphology, The Medical College of The University of Rzeszów, Rzeszów, Poland.
      Authors
    • Osuchowski M 1
    (1 author)
  • 2. Department of Biochemistry and General Chemistry, The Medical College of The University of Rzeszów, Rzeszów, Poland.
      Authors
    • Bartusik-Aebisher D 2
    (1 author)
  • 3. Department of Health Sciences, The Medical College of The University of Rzeszów, Rzeszów, Poland.
      Authors
    • Osuchowski F 3
    (1 author)
  • 4. Department of Photomedicine and Physical Sciences, The Medical College of The University of Rzeszów, Rzeszów, Poland.
      Authors
    • Aebisher D 4
    (1 author)

ORCIDs linked to this article

Photodiagnosis and Photodynamic Therapy, 19 Dec 2020, 33:102158
https://doi.org/10.1016/j.pdpdt.2020.102158 PMID: 33352313 

Review

Abstract 

This article is a review of approaches to treatment of low and high-grade prostate cancer including a discussion of active treatment vs. active surveillance for patients with low-grade prostate cancer. In particular, we will review PDT as an option for active treatment of low-grade prostate cancer considered in light of recent clinical trials. The mechanism and clinical methods of PDT application and the key points from clinical trials using PDT for prostate cancer with the photosensitizers m-tetrahydroxyphenyl chloride, protoporphyrin IX, motexafin lutetium, padoporfin, and padeliporfin between the years 2002 and 2017 are reviewed. Recently developed methodologies for photodynamic prostate cancer treatment that are in the experimental stage, photodynamic diagnosis, fluorescence guided resection, and PSMA-targeted PDT will also be discussed.

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Read article at publisher's site: https://doi.org/10.1016/j.pdpdt.2020.102158

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