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Bacteriophage-resistant Acinetobacter baumannii are resensitized to antimicrobials.

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Affiliations

  • 1. School of Biological Sciences, Monash University, Clayton, Victoria, Australia.
      Authors
    • Gordillo Altamirano F 1
    • Forsyth JH 1
    • Patwa R 1
    • Trim M 1
    • Subedi D 1
    • Oliveira C 1
    • Kielty L 1
    • Korneev D 1
    • O'Bryan MK 1
    • Barr JJ 1
    (10 authors)
  • 2. Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Victoria, Australia.
      Authors
    • Kostoulias X 2
    • Morris FC 2
    • Lithgow TJ 2
    • Peleg AY 2
    (4 authors)
  • 3. Monash Bioinformatics Platform, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia.
      Authors
    • Archer SK 3
    (1 author)

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Nature Microbiology, 11 Jan 2021, 6(2):157-161
https://doi.org/10.1038/s41564-020-00830-7 PMID: 33432151 

This article is based on a previously available preprint.

Abstract 

We characterized two bacteriophages, ΦFG02 and ΦCO01, against clinical isolates of Acinetobacter baumannii and established that the bacterial capsule is the receptor for these phages. Phage-resistant mutants harboured loss-of-function mutations in genes responsible for capsule biosynthesis, resulting in capsule loss and disruption of phage adsorption. The phage-resistant strains were resensitized to human complement, beta-lactam antibiotics and alternative phages and exhibited diminished fitness in vivo. Using a mouse model of A. baumannii infection, we showed that phage therapy was effective.

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Read article at publisher's site: https://doi.org/10.1038/s41564-020-00830-7

Read article for free, from open access legal sources, via Unpaywall: https://www.biorxiv.org/content/biorxiv/early/2020/02/26/2020.02.25.965590.full.pdfUnpaywall

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