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Bone and joint infections caused by Clostridium perfringens: a case series.

Author information

Affiliations

  • 1. Department of Internal Medicine and Infectious Diseases, Reims Teaching Hospitals, Avenue du Général Koenig, 51092, Reims, France.
      Authors
    • Visse M 1
    • Hentzien M 1
    • Bani-Sadr F 1
    (3 authors)
  • 2. Department of Bacteriology, Reims Teaching Hospitals, Reims, France.
      Authors
    • Vernet-Garnier V 2
    (1 author)
  • 3. Department of Hygiene, Reims Teaching Hospitals, Reims, France.
      Authors
    • Bajolet O 3
    (1 author)
  • 4. Department of Internal Medicine and Infectious Diseases, Manchester Hospital, Charleville-Mezieres, France.
      Authors
    • Lebrun D 4
    (1 author)
  • 5. Department of Pharmacy, Reims Teaching Hospitals, Reims, France.
      Authors
    • Bonnet M 5
    (1 author)
    • Show all (6)

ORCIDs linked to this article

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology, 16 Mar 2021, 40(10):2221-2225
https://doi.org/10.1007/s10096-021-04225-2 PMID: 33723737 

Abstract 

The objective of this study was to evaluate antimicrobial therapy outcomes of bone and joint infections (BJI) caused by Clostridium perfringens. We investigated remission of symptoms and the absence of relapse or reinfection during follow-up. Among the 8 patients with C. perfringens BJI, the type of infection was early prosthesis infection (n = 2), osteosynthetic device infection (n = 4), and chronic osteomyeletis (n = 2). Clindamycin-rifampicin combination was given in 4 cases and metronidazole in 4 cases. The overall success rate was 87.5%. Among the 7 patients who completed antibiotic treatment, the success rate was 100%. The clindamycin-rifampicin combination appeared to be effective in patients with C. perfringens BJI.

Full text links 

Read article at publisher's site: https://doi.org/10.1007/s10096-021-04225-2

References 

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