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Ion Channel Degeneracy, Variability, and Covariation in Neuron and Circuit Resilience.

Author information

Affiliations

  • 1. UMR_S 1072, Aix-Marseille Université, INSERM, 13015 Marseille, France.
      Authors
    • Goaillard JM 1
    (1 author)
  • 2. Volen Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA;
      Authors
    • Marder E 2
    (1 author)

ORCIDs linked to this article

Annual Review of Neuroscience, 26 Mar 2021, 44:335-357
https://doi.org/10.1146/annurev-neuro-092920-121538 PMID: 33770451 

Abstract 

The large number of ion channels found in all nervous systems poses fundamental questions concerning how the characteristic intrinsic properties of single neurons are determined by the specific subsets of channels they express. All neurons display many different ion channels with overlapping voltage- and time-dependent properties. We speculate that these overlapping properties promote resilience in neuronal function. Individual neurons of the same cell type show variability in ion channel conductance densities even though they can generate reliable and similar behavior. This complicates a simple assignment of function to any conductance and is associated with variable responses of neurons of the same cell type to perturbations, deletions, and pharmacological manipulation. Ion channel genes often show strong positively correlated expression, which may result from the molecular and developmental rules that determine which ion channels are expressed in a given cell type.

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Read article at publisher's site: https://doi.org/10.1146/annurev-neuro-092920-121538

Read article for free, from open access legal sources, via Unpaywall: https://www.annualreviews.org/doi/pdf/10.1146/annurev-neuro-092920-121538Unpaywall

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Funding 

Funders who supported this work.

NINDS NIH HHS (1)