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Size-dependent enhancement on conjugative transfer of antibiotic resistance genes by micro/nanoplastics.

Author information

Affiliations

  • 1. Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Key Laboratory of Philosophy and Social Science in Guangdong Province of Community of Life for Man and Nature, Jinan University, Guangzhou 510632, China; CAS Key Laboratory of Soil Environment and Pollution Remediation, Institute of Soil Science, Chinese Academy of Sciences, Nanjing 210008, China.
      Authors
    • Zha Y 1
    • Hou S 1
    (2 authors)
  • 2. Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Key Laboratory of Philosophy and Social Science in Guangdong Province of Community of Life for Man and Nature, Jinan University, Guangzhou 510632, China.
      Authors
    • Li Z 2
    • Zhong Z 2
    • Ruan Y 2
    (3 authors)
  • 3. Guangzhou Inspection Testing and Certification Group Co., Ltd., China.
      Authors
    • Sun L 3
    (1 author)
  • 4. Guangzhou Inspection Testing and Certification Group Co., Ltd., China; Key Laboratory for Quality Research and Evaluation of Medical Textile Protective Products, Guangdong Medical Products Administration, China.
      Authors
    • Zuo F 4
    (1 author)
  • 5. State Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment, Center for Environmental Health Research, South China Institute of Environmental Sciences, Ministry of Ecology and Environment, Guangzhou 510655, China.
      Authors
    • Li L 5
    (1 author)

Journal of Hazardous Materials, 23 Feb 2022, 431:128561
https://doi.org/10.1016/j.jhazmat.2022.128561 PMID: 35278945 

Abstract 

Recently micro/nanoplastics (MNPs) have raised intensive concerns due to their possible enhancement effect on the dissemination of antibiotic genes. Unfortunately, data is still lacking to verify the effect. In the study, the influence of polystyrene MNPs on the conjugative gene transfer was studied by using E. coli DH5ɑ with RP4 plasmid as the donor bacteria and E. coli K12 MG1655 as the recipient bacteria. We found that influence of MNPs on gene transfer was size-dependent. Small MNPs (10 nm in radius) caused an increase and then a decrease in gene transfer efficiency with their concentration increasing. Moderate-sized MNPs (50 nm in radius) caused an increase in gene transfer efficiency. Large MNPs (500 nm in radius) had almost no influence on gene transfer. The gene transfer could be further enhanced by optimizing mating time and mating ratio. Scavenging reactive oxygen species (ROS) production did not affect the cell membrane permeability, indicating that the increase in cell membrane permeability was not related to ROS production. The mechanism of the enhanced gene transfer efficiency was attributed to a combined effect of the increased ROS production and the increased cell membrane permeability, which ultimately regulated the expression of corresponding genes.

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Read article at publisher's site: https://doi.org/10.1016/j.jhazmat.2022.128561

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