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The role of Pycnogenol in the control of inflammation and oxidative stress in chronic diseases: Molecular aspects.

Author information

Affiliations

  • 1. Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
      Authors
    • Nattagh-Eshtivani E 1, 5
    • Gheflati A 1, 5
    • Barghchi H 1, 5
    • Rahbarinejad P 1, 5
    (4 authors)
  • 2. Laboratory of Biotoxicology, Pharmacognosy and Biological Valorization of Plants (LBPVBP), Faculty of Sciences, University of Saida- Dr Moulay Tahar, Saida, Algeria.
      Authors
    • Hachem K 2
    (1 author)
  • 3. Biological Sciences and Sports Health Department, Faculty of Physical Education, Suez Canal University, Ismailia, Egypt.
      Authors
    • Shalaby MN 3
    (1 author)
  • 4. Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al Kharj, Saudi Arabia.
      Authors
    • Abdelbasset WK 4
    (1 author)
  • 5. Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
      Authors
    • Nattagh-Eshtivani E 1, 5
    • Gheflati A 1, 5
    • Barghchi H 1, 5
    • Rahbarinejad P 1, 5
    • Ranjbar G 5
    (5 authors)
    • Show all (9)

ORCIDs linked to this article

Phytotherapy Research : PTR, 18 May 2022, 36(6):2352-2374
https://doi.org/10.1002/ptr.7454 PMID: 35583807 

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Abstract 

The prevalence of chronic diseases has increased significantly with the rising trend of sedentary lifestyles, reduced physical activity, and dietary modifications in recent decades. Inflammation and oxidative stress play a key role in the pathophysiology of several chronic diseases, such as type II diabetes, cardiovascular diseases, and hepatic conditions. Therefore, reducing inflammation and oxidative stress may be beneficial in the prevention and treatment of various chronic disorders. Since chronic diseases are not completely curable, various methods have been proposed for their control. Complementary therapies and the use of natural antioxidant and antiinflammatory compounds are among these novel approaches. Pycnogenol (PYC) is a natural compound that could control inflammation and oxidative stress. Furthermore, some previous studies have shown that PYC could effectively reduce inflammation through signaling the downstream of insulin receptors, inhibiting the phosphorylation of the serine residues of insulin receptor substrate-1, reducing pro-inflammatory cytokines and oxidative stress indices through the stimulation of antioxidant pathways, increasing free radical scavenging activities, preventing lipid peroxidation, and protecting the erythrocytes in glucose-6-phosphate dehydrogenase-deficient individuals, although these effects have not been fully proved. The present study aimed to comprehensively review the evidence concerning the positive physiological and pharmacological properties of PYC, with an emphasis on the therapeutic potential of this natural component for enhancing human health.

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Read article at publisher's site: https://doi.org/10.1002/ptr.7454

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